Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease
The effect of bromocriptine, a dopamine agonist, administered in the form of bromocriptine alginate nanocomposite (BANC) was studied on Parkinson's disease (PD) model flies. The synthesized BANC was subject to characterization and, at a final concentration of 0.5, 1.0 and 1.5 µM, was mixed in d...
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2016-01-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/9/1/63 |
| _version_ | 1818118100247117824 |
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| author | Yasir Hasan Siddique Wasi Khan Ambreen Fatima Smita Jyoti Saba Khanam Falaq Naz Rahul Fahad Ali Braj Raj Singh Alim Hussain Naqvi |
| author_facet | Yasir Hasan Siddique Wasi Khan Ambreen Fatima Smita Jyoti Saba Khanam Falaq Naz Rahul Fahad Ali Braj Raj Singh Alim Hussain Naqvi |
| author_sort | Yasir Hasan Siddique |
| collection | DOAJ |
| description | The effect of bromocriptine, a dopamine agonist, administered in the form of bromocriptine alginate nanocomposite (BANC) was studied on Parkinson's disease (PD) model flies. The synthesized BANC was subject to characterization and, at a final concentration of 0.5, 1.0 and 1.5 µM, was mixed in diet. The PD flies were allowed to feed on it for 24 days. A significant dose-dependent delay in the loss of climbing activity and activity pattern was observed in PD flies exposed to 0.5, 1.0 and 1.5 µM BANC. The PD flies exposed to BANC also showed a significant reduction in lipid peroxidation and glutathione-S-transferase activity, and an increase in glutathione content. However, no gross morphological changes were observed in the brains of PD flies compared with controls. The results suggest that BANC is effective in reducing the PD symptoms in these transgenic flies. |
| first_indexed | 2024-12-11T04:48:56Z |
| format | Article |
| id | doaj.art-5bc5565820d2458bbc6ce114d67111da |
| institution | Directory Open Access Journal |
| issn | 1754-8411 1754-8403 |
| language | English |
| last_indexed | 2024-12-11T04:48:56Z |
| publishDate | 2016-01-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-5bc5565820d2458bbc6ce114d67111da2022-12-22T01:20:27ZengThe Company of BiologistsDisease Models & Mechanisms1754-84111754-84032016-01-0191636810.1242/dmm.022145022145Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's diseaseYasir Hasan Siddique0Wasi Khan1Ambreen Fatima2Smita Jyoti3Saba Khanam4Falaq Naz5Rahul6Fahad Ali7Braj Raj Singh8Alim Hussain Naqvi9 Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India Centre of Excellence in Materials Sciences (Nanomaterials), Department of Applied Physics, Z. H. College of Engineering & Technology, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India Centre of Excellence in Materials Sciences (Nanomaterials), Department of Applied Physics, Z. H. College of Engineering & Technology, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India Centre of Excellence in Materials Sciences (Nanomaterials), Department of Applied Physics, Z. H. College of Engineering & Technology, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India The effect of bromocriptine, a dopamine agonist, administered in the form of bromocriptine alginate nanocomposite (BANC) was studied on Parkinson's disease (PD) model flies. The synthesized BANC was subject to characterization and, at a final concentration of 0.5, 1.0 and 1.5 µM, was mixed in diet. The PD flies were allowed to feed on it for 24 days. A significant dose-dependent delay in the loss of climbing activity and activity pattern was observed in PD flies exposed to 0.5, 1.0 and 1.5 µM BANC. The PD flies exposed to BANC also showed a significant reduction in lipid peroxidation and glutathione-S-transferase activity, and an increase in glutathione content. However, no gross morphological changes were observed in the brains of PD flies compared with controls. The results suggest that BANC is effective in reducing the PD symptoms in these transgenic flies.http://dmm.biologists.org/content/9/1/63BromocriptineNanocompositeParkinson's disease |
| spellingShingle | Yasir Hasan Siddique Wasi Khan Ambreen Fatima Smita Jyoti Saba Khanam Falaq Naz Rahul Fahad Ali Braj Raj Singh Alim Hussain Naqvi Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease Disease Models & Mechanisms Bromocriptine Nanocomposite Parkinson's disease |
| title | Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease |
| title_full | Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease |
| title_fullStr | Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease |
| title_full_unstemmed | Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease |
| title_short | Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease |
| title_sort | effect of bromocriptine alginate nanocomposite banc on a transgenic drosophila model of parkinson s disease |
| topic | Bromocriptine Nanocomposite Parkinson's disease |
| url | http://dmm.biologists.org/content/9/1/63 |
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