Tetanus in Animals — Summary of Knowledge
Tetanus is a neurologic non-transmissible disease (often fatal) of humans and other animals with a worldwide occurrence. Clostridium tetani is the spore producing bacillus which causes the bacterial disease. In deep penetrating wounds the spores germinate and produce a toxin called tetanospasmin. Th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2020-09-01
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| Series: | Folia Veterinaria |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/fv-2020-0027 |
| _version_ | 1818691202828992512 |
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| author | Malinovská Z. Čonková E. Váczi P. |
| author_facet | Malinovská Z. Čonková E. Váczi P. |
| author_sort | Malinovská Z. |
| collection | DOAJ |
| description | Tetanus is a neurologic non-transmissible disease (often fatal) of humans and other animals with a worldwide occurrence. Clostridium tetani is the spore producing bacillus which causes the bacterial disease. In deep penetrating wounds the spores germinate and produce a toxin called tetanospasmin. The main characteristic sign of tetanus is a spastic paralysis. A diagnosis is usually based on the clinical signs because the detection in the wound and the cultivation of C. tetani is very difficult. Between animal species there is considerable variability in the susceptibility to the bacillus. The most sensitive animal species to the neurotoxin are horses. Sheep and cattle are less sensitive and tetanus in these animal species are less common. Tetanus in cats and dogs are rare and dogs are less sensitive than cats. Clinically two forms of tetanus have been recognized, i. e. localized and generalized. The available treatment is not specific because the toxin in neuronal cells cannot be accessed by antitoxin antibodies. The aim of the therapy is to: neutralise the unbound neurotoxin, inhibit C. tetani growth in the wound, and provide supportive care to mitigate the effects of the neurotoxin. The treatment is difficult with an unclear prognosis. |
| first_indexed | 2024-12-17T12:38:09Z |
| format | Article |
| id | doaj.art-5bc5e14e54e74e078da09dee0d62015a |
| institution | Directory Open Access Journal |
| issn | 2453-7837 |
| language | English |
| last_indexed | 2024-12-17T12:38:09Z |
| publishDate | 2020-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Folia Veterinaria |
| spelling | doaj.art-5bc5e14e54e74e078da09dee0d62015a2022-12-21T21:48:10ZengSciendoFolia Veterinaria2453-78372020-09-01643546010.2478/fv-2020-0027fv-2020-0027Tetanus in Animals — Summary of KnowledgeMalinovská Z.0Čonková E.1Váczi P.2Department of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81KošiceSlovakiaDepartment of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81KošiceSlovakiaDepartment of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81KošiceSlovakiaTetanus is a neurologic non-transmissible disease (often fatal) of humans and other animals with a worldwide occurrence. Clostridium tetani is the spore producing bacillus which causes the bacterial disease. In deep penetrating wounds the spores germinate and produce a toxin called tetanospasmin. The main characteristic sign of tetanus is a spastic paralysis. A diagnosis is usually based on the clinical signs because the detection in the wound and the cultivation of C. tetani is very difficult. Between animal species there is considerable variability in the susceptibility to the bacillus. The most sensitive animal species to the neurotoxin are horses. Sheep and cattle are less sensitive and tetanus in these animal species are less common. Tetanus in cats and dogs are rare and dogs are less sensitive than cats. Clinically two forms of tetanus have been recognized, i. e. localized and generalized. The available treatment is not specific because the toxin in neuronal cells cannot be accessed by antitoxin antibodies. The aim of the therapy is to: neutralise the unbound neurotoxin, inhibit C. tetani growth in the wound, and provide supportive care to mitigate the effects of the neurotoxin. The treatment is difficult with an unclear prognosis.https://doi.org/10.2478/fv-2020-0027animalclostridium tetanitoxinspasmtreatment |
| spellingShingle | Malinovská Z. Čonková E. Váczi P. Tetanus in Animals — Summary of Knowledge Folia Veterinaria animal clostridium tetani toxin spasm treatment |
| title | Tetanus in Animals — Summary of Knowledge |
| title_full | Tetanus in Animals — Summary of Knowledge |
| title_fullStr | Tetanus in Animals — Summary of Knowledge |
| title_full_unstemmed | Tetanus in Animals — Summary of Knowledge |
| title_short | Tetanus in Animals — Summary of Knowledge |
| title_sort | tetanus in animals summary of knowledge |
| topic | animal clostridium tetani toxin spasm treatment |
| url | https://doi.org/10.2478/fv-2020-0027 |
| work_keys_str_mv | AT malinovskaz tetanusinanimalssummaryofknowledge AT conkovae tetanusinanimalssummaryofknowledge AT vaczip tetanusinanimalssummaryofknowledge |