The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence
Psychiatric disorders represent a great medical and social challenge and people suffering from these conditions face many impairments regarding personal and professional life. In addition, a mental disorder will manifest itself in approximately one quarter of the world's population at some peri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-09-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2017.00493/full |
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| author | Giuliana S. Zuccoli Giuliana S. Zuccoli Verônica M. Saia-Cereda Verônica M. Saia-Cereda Juliana M. Nascimento Juliana M. Nascimento Daniel Martins-de-Souza Daniel Martins-de-Souza |
| author_facet | Giuliana S. Zuccoli Giuliana S. Zuccoli Verônica M. Saia-Cereda Verônica M. Saia-Cereda Juliana M. Nascimento Juliana M. Nascimento Daniel Martins-de-Souza Daniel Martins-de-Souza |
| author_sort | Giuliana S. Zuccoli |
| collection | DOAJ |
| description | Psychiatric disorders represent a great medical and social challenge and people suffering from these conditions face many impairments regarding personal and professional life. In addition, a mental disorder will manifest itself in approximately one quarter of the world's population at some period of their life. Dysfunction in energy metabolism is one of the most consistent scientific findings associated with these disorders. With this is mind, this review compiled data on disturbances in energy metabolism found by proteomic analyses of postmortem brains collected from patients affected by the most prevalent psychiatric disorders: schizophrenia (SCZ), bipolar disorder (BPD), and major depressive disorder (MDD). We searched in the PubMed database to gather the studies and compiled all the differentially expressed proteins reported in each work. SCZ studies revealed 92 differentially expressed proteins related to energy metabolism, while 95 proteins were discovered in BPD, and 41 proteins in MDD. With the compiled data, it was possible to determine which proteins related to energy metabolism were found to be altered in all the disorders as well as which ones were altered exclusively in one of them. In conclusion, the information gathered in this work could contribute to a better understanding of the impaired metabolic mechanisms and hopefully bring insights into the underlying neuropathology of psychiatric disorders. |
| first_indexed | 2024-12-21T03:15:15Z |
| format | Article |
| id | doaj.art-5bc620691f5344e1947a183f4043587c |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-21T03:15:15Z |
| publishDate | 2017-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-5bc620691f5344e1947a183f4043587c2022-12-21T19:17:51ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-09-011110.3389/fnins.2017.00493277593The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic EvidenceGiuliana S. Zuccoli0Giuliana S. Zuccoli1Verônica M. Saia-Cereda2Verônica M. Saia-Cereda3Juliana M. Nascimento4Juliana M. Nascimento5Daniel Martins-de-Souza6Daniel Martins-de-Souza7Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of CampinasCampinas, BrazilInstituto Nacional de Biomarcadores em Neuropsiquiatria (INBION), Conselho Nacional de Desenvolvimento Cientifico e TecnologicoSão Paulo, BrazilLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of CampinasCampinas, BrazilInstituto Nacional de Biomarcadores em Neuropsiquiatria (INBION), Conselho Nacional de Desenvolvimento Cientifico e TecnologicoSão Paulo, BrazilLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of CampinasCampinas, BrazilInstituto Nacional de Biomarcadores em Neuropsiquiatria (INBION), Conselho Nacional de Desenvolvimento Cientifico e TecnologicoSão Paulo, BrazilLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of CampinasCampinas, BrazilInstituto Nacional de Biomarcadores em Neuropsiquiatria (INBION), Conselho Nacional de Desenvolvimento Cientifico e TecnologicoSão Paulo, BrazilPsychiatric disorders represent a great medical and social challenge and people suffering from these conditions face many impairments regarding personal and professional life. In addition, a mental disorder will manifest itself in approximately one quarter of the world's population at some period of their life. Dysfunction in energy metabolism is one of the most consistent scientific findings associated with these disorders. With this is mind, this review compiled data on disturbances in energy metabolism found by proteomic analyses of postmortem brains collected from patients affected by the most prevalent psychiatric disorders: schizophrenia (SCZ), bipolar disorder (BPD), and major depressive disorder (MDD). We searched in the PubMed database to gather the studies and compiled all the differentially expressed proteins reported in each work. SCZ studies revealed 92 differentially expressed proteins related to energy metabolism, while 95 proteins were discovered in BPD, and 41 proteins in MDD. With the compiled data, it was possible to determine which proteins related to energy metabolism were found to be altered in all the disorders as well as which ones were altered exclusively in one of them. In conclusion, the information gathered in this work could contribute to a better understanding of the impaired metabolic mechanisms and hopefully bring insights into the underlying neuropathology of psychiatric disorders.http://journal.frontiersin.org/article/10.3389/fnins.2017.00493/fullproteomeschizophreniadepressionbipolar disordermass spectrometry |
| spellingShingle | Giuliana S. Zuccoli Giuliana S. Zuccoli Verônica M. Saia-Cereda Verônica M. Saia-Cereda Juliana M. Nascimento Juliana M. Nascimento Daniel Martins-de-Souza Daniel Martins-de-Souza The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence Frontiers in Neuroscience proteome schizophrenia depression bipolar disorder mass spectrometry |
| title | The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence |
| title_full | The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence |
| title_fullStr | The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence |
| title_full_unstemmed | The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence |
| title_short | The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence |
| title_sort | energy metabolism dysfunction in psychiatric disorders postmortem brains focus on proteomic evidence |
| topic | proteome schizophrenia depression bipolar disorder mass spectrometry |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2017.00493/full |
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