High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinoma
Abstract Background Fibroblast‐activating protein (FAP) is expressed in cancer‐associated fibroblasts (CAFs) in many human carcinomas and in some types of carcinoma cells. Here, we examined the proportion of FAP protein expression in non‐small cell lung carcinoma (NSCLC) and investigated the correla...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.14579 |
| _version_ | 1811320879495249920 |
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| author | Naoki Yanagawa Mayu Sugai Shunsuke Shikanai Ryo Sugimoto Mitsumasa Osakabe Noriyuki Uesugi Hajime Saito Makoto Maemondo Tamotsu Sugai |
| author_facet | Naoki Yanagawa Mayu Sugai Shunsuke Shikanai Ryo Sugimoto Mitsumasa Osakabe Noriyuki Uesugi Hajime Saito Makoto Maemondo Tamotsu Sugai |
| author_sort | Naoki Yanagawa |
| collection | DOAJ |
| description | Abstract Background Fibroblast‐activating protein (FAP) is expressed in cancer‐associated fibroblasts (CAFs) in many human carcinomas and in some types of carcinoma cells. Here, we examined the proportion of FAP protein expression in non‐small cell lung carcinoma (NSCLC) and investigated the correlation of FAP expression with clinicopathological background. Methods In total, 344 NSCLC tissues were examined. Tissue microarrays were constructed, and FAP expression was analyzed using immunohistochemistry. The status of FAP expression in tumor cells and CAFs was correlated with clinicopathological background, molecular features, and patient outcomes. Results A total of 280 patients (81.4%) had low FAP expression, and 64 patients (18.6%) had high FAP expression in tumor cells. In CAFs, 230 patients (66.9%) had low FAP expression, and 114 patients (33.1%) had high FAP expression. In multivariate analyses, high FAP expression in tumor cells was an independent predictive factor of both overall survival (OS; hazard ratio [HR] = 2.57, 95% confidence interval [CI]: 1.49–4.42, p < 0.001) and recurrence‐free survival (RFS; HR = 2.13, 95% CI: 1.38–3.29, p < 0.001). Based on combinations of FAP expression in tumor cells and CAFs, patients with LowT/LowCAFs had better OS and RFS than did those in the other subgroups. By contrast, patients with HighT/HighCAFs had poor OS and RFS compared with those in the other subgroups. Conclusions Overall, FAP expression in tumor cells and the combination FAP expression in tumor cells and CAFs were strongly associated with patient survival and may be useful predictive biomarkers for patient outcomes in NSCLC. |
| first_indexed | 2024-04-13T13:08:18Z |
| format | Article |
| id | doaj.art-5bc6d9ceb62f4a5b92f8b8f03931ed00 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-13T13:08:18Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-5bc6d9ceb62f4a5b92f8b8f03931ed002022-12-22T02:45:42ZengWileyThoracic Cancer1759-77061759-77142022-08-0113162377238410.1111/1759-7714.14579High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinomaNaoki Yanagawa0Mayu Sugai1Shunsuke Shikanai2Ryo Sugimoto3Mitsumasa Osakabe4Noriyuki Uesugi5Hajime Saito6Makoto Maemondo7Tamotsu Sugai8Department of Molecular Diagnostic Pathology Iwate Medical University Shiwa‐gun JapanDepartment of Molecular Diagnostic Pathology Iwate Medical University Shiwa‐gun JapanDepartment of Molecular Diagnostic Pathology Iwate Medical University Shiwa‐gun JapanDepartment of Molecular Diagnostic Pathology Iwate Medical University Shiwa‐gun JapanDepartment of Molecular Diagnostic Pathology Iwate Medical University Shiwa‐gun JapanDepartment of Molecular Diagnostic Pathology Iwate Medical University Shiwa‐gun JapanDepartment of Thoracic Surgery Iwate Medical University Shiwa‐gun JapanDivision of Pulmonary Medicine, Department of Internal Medicine Iwate Medical University Shiwa‐gun JapanDepartment of Molecular Diagnostic Pathology Iwate Medical University Shiwa‐gun JapanAbstract Background Fibroblast‐activating protein (FAP) is expressed in cancer‐associated fibroblasts (CAFs) in many human carcinomas and in some types of carcinoma cells. Here, we examined the proportion of FAP protein expression in non‐small cell lung carcinoma (NSCLC) and investigated the correlation of FAP expression with clinicopathological background. Methods In total, 344 NSCLC tissues were examined. Tissue microarrays were constructed, and FAP expression was analyzed using immunohistochemistry. The status of FAP expression in tumor cells and CAFs was correlated with clinicopathological background, molecular features, and patient outcomes. Results A total of 280 patients (81.4%) had low FAP expression, and 64 patients (18.6%) had high FAP expression in tumor cells. In CAFs, 230 patients (66.9%) had low FAP expression, and 114 patients (33.1%) had high FAP expression. In multivariate analyses, high FAP expression in tumor cells was an independent predictive factor of both overall survival (OS; hazard ratio [HR] = 2.57, 95% confidence interval [CI]: 1.49–4.42, p < 0.001) and recurrence‐free survival (RFS; HR = 2.13, 95% CI: 1.38–3.29, p < 0.001). Based on combinations of FAP expression in tumor cells and CAFs, patients with LowT/LowCAFs had better OS and RFS than did those in the other subgroups. By contrast, patients with HighT/HighCAFs had poor OS and RFS compared with those in the other subgroups. Conclusions Overall, FAP expression in tumor cells and the combination FAP expression in tumor cells and CAFs were strongly associated with patient survival and may be useful predictive biomarkers for patient outcomes in NSCLC.https://doi.org/10.1111/1759-7714.14579fibroblast‐activating proteinimmunohistochemistrynon‐small cell lung carcinomaprognosis |
| spellingShingle | Naoki Yanagawa Mayu Sugai Shunsuke Shikanai Ryo Sugimoto Mitsumasa Osakabe Noriyuki Uesugi Hajime Saito Makoto Maemondo Tamotsu Sugai High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinoma Thoracic Cancer fibroblast‐activating protein immunohistochemistry non‐small cell lung carcinoma prognosis |
| title | High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinoma |
| title_full | High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinoma |
| title_fullStr | High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinoma |
| title_full_unstemmed | High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinoma |
| title_short | High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinoma |
| title_sort | high expression of fibroblast activating protein is a prognostic marker in non small cell lung carcinoma |
| topic | fibroblast‐activating protein immunohistochemistry non‐small cell lung carcinoma prognosis |
| url | https://doi.org/10.1111/1759-7714.14579 |
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