A Single Center, Prospective, Randomized, Blinded Study to Evaluate the Efficacy and Safety of a Topical Tripeptide/Hexapeptide Anhydrous Gel When Used Pre- and Post- Hybrid Fractional Laser for the Treatment of Acne Scars
Mara Weinstein Velez,1 James Prezzano,1,2 Michaela Bell,3 Alan Widgerow3,4 1Department of Dermatology, University of Rochester, Rochester, NY, USA; 2Fayetteville Dermatology, Fayetteville, NY, USA; 3Clinical Research Dept, Alastin® Skincare, Inc. (A Galderma Company), Carlsbad, CA, USA; 4Plastic Sur...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-12-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
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| Online Access: | https://www.dovepress.com/a-single-center-prospective-randomized-blinded-study-to-evaluate-the-e-peer-reviewed-fulltext-article-CCID |
| _version_ | 1811291383154081792 |
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| author | Weinstein Velez M Prezzano J Bell M Widgerow A |
| author_facet | Weinstein Velez M Prezzano J Bell M Widgerow A |
| author_sort | Weinstein Velez M |
| collection | DOAJ |
| description | Mara Weinstein Velez,1 James Prezzano,1,2 Michaela Bell,3 Alan Widgerow3,4 1Department of Dermatology, University of Rochester, Rochester, NY, USA; 2Fayetteville Dermatology, Fayetteville, NY, USA; 3Clinical Research Dept, Alastin® Skincare, Inc. (A Galderma Company), Carlsbad, CA, USA; 4Plastic Surgery Dept, Center for Tissue Engineering, University of California Irvine, Irvine, CA, USACorrespondence: Alan Widgerow, Email alan.widgerow@galderma.comBackground: Acne scarring remains a significant problem. Laser therapy has produced varying results with deeper ablative therapies occasionally associated with side effects including delayed healing, infection, scarring, erythema, acne, milia, edema and dyspigmentation.Objective: Can adjuvant topical therapy impact the healing process and outcome of patients treated with fractional laser for acne scarring?Methods and Materials: Ten patients were randomized to receive either Regenerating Skin Nectar with TriHex Technology®– RSN or a bland moisturizer. Patients underwent two laser procedures one month apart with Hybrid Fractional Laser. The topical was applied twice daily for 2 weeks prior to the first laser procedure, and through completion of the study. Seven study visits occurred over a 90-day period. Measurements were conducted in lesional and non-lesional areas – transepidermal water loss (TEWL), erythema, photography, Goodman and Baron qualitative scale, Global Aesthetic Improvement Scale and patient questionnaires – to assess functional recovery and aesthetic outcomes in the scarred areas. One patient from each cohort consented to biopsy before the procedures and 90 days after the first procedure.Results: Reduced TEWL scores in the RSN group were evident at all time points with statistically significant reductions occurring 4 days after first and second procedures indicating more efficient fluid conservation at a critical point in the healing trajectory. Erythema index demonstrated a consistent decrease in the RSN cohort over the control from day 4 through day 90 on lesional and non-lesional skin. Acne scar assessment scores improved in the RSN cohort compared with the control at all time points. Biopsy results showed early elastin regeneration in the RSN biopsy with controlled non-hypertrophic collagen formation evident.Conclusion: The use of RSN pre- and post- laser resurfacing significantly decreased postprocedural TEWL and erythema, and increased aesthetic improvement in acne scars and patient satisfaction, when compared with bland moisturizer.Keywords: acne scars, laser resurfacing, post procedure, topical |
| first_indexed | 2024-04-13T04:28:33Z |
| format | Article |
| id | doaj.art-5bc6fa8837d743e4a9fdbd9be09a43a8 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-04-13T04:28:33Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-5bc6fa8837d743e4a9fdbd9be09a43a82022-12-22T03:02:25ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152022-12-01Volume 152763277480404A Single Center, Prospective, Randomized, Blinded Study to Evaluate the Efficacy and Safety of a Topical Tripeptide/Hexapeptide Anhydrous Gel When Used Pre- and Post- Hybrid Fractional Laser for the Treatment of Acne ScarsWeinstein Velez MPrezzano JBell MWidgerow AMara Weinstein Velez,1 James Prezzano,1,2 Michaela Bell,3 Alan Widgerow3,4 1Department of Dermatology, University of Rochester, Rochester, NY, USA; 2Fayetteville Dermatology, Fayetteville, NY, USA; 3Clinical Research Dept, Alastin® Skincare, Inc. (A Galderma Company), Carlsbad, CA, USA; 4Plastic Surgery Dept, Center for Tissue Engineering, University of California Irvine, Irvine, CA, USACorrespondence: Alan Widgerow, Email alan.widgerow@galderma.comBackground: Acne scarring remains a significant problem. Laser therapy has produced varying results with deeper ablative therapies occasionally associated with side effects including delayed healing, infection, scarring, erythema, acne, milia, edema and dyspigmentation.Objective: Can adjuvant topical therapy impact the healing process and outcome of patients treated with fractional laser for acne scarring?Methods and Materials: Ten patients were randomized to receive either Regenerating Skin Nectar with TriHex Technology®– RSN or a bland moisturizer. Patients underwent two laser procedures one month apart with Hybrid Fractional Laser. The topical was applied twice daily for 2 weeks prior to the first laser procedure, and through completion of the study. Seven study visits occurred over a 90-day period. Measurements were conducted in lesional and non-lesional areas – transepidermal water loss (TEWL), erythema, photography, Goodman and Baron qualitative scale, Global Aesthetic Improvement Scale and patient questionnaires – to assess functional recovery and aesthetic outcomes in the scarred areas. One patient from each cohort consented to biopsy before the procedures and 90 days after the first procedure.Results: Reduced TEWL scores in the RSN group were evident at all time points with statistically significant reductions occurring 4 days after first and second procedures indicating more efficient fluid conservation at a critical point in the healing trajectory. Erythema index demonstrated a consistent decrease in the RSN cohort over the control from day 4 through day 90 on lesional and non-lesional skin. Acne scar assessment scores improved in the RSN cohort compared with the control at all time points. Biopsy results showed early elastin regeneration in the RSN biopsy with controlled non-hypertrophic collagen formation evident.Conclusion: The use of RSN pre- and post- laser resurfacing significantly decreased postprocedural TEWL and erythema, and increased aesthetic improvement in acne scars and patient satisfaction, when compared with bland moisturizer.Keywords: acne scars, laser resurfacing, post procedure, topicalhttps://www.dovepress.com/a-single-center-prospective-randomized-blinded-study-to-evaluate-the-e-peer-reviewed-fulltext-article-CCIDacne scarslaser resurfacingpost proceduretopical |
| spellingShingle | Weinstein Velez M Prezzano J Bell M Widgerow A A Single Center, Prospective, Randomized, Blinded Study to Evaluate the Efficacy and Safety of a Topical Tripeptide/Hexapeptide Anhydrous Gel When Used Pre- and Post- Hybrid Fractional Laser for the Treatment of Acne Scars Clinical, Cosmetic and Investigational Dermatology acne scars laser resurfacing post procedure topical |
| title | A Single Center, Prospective, Randomized, Blinded Study to Evaluate the Efficacy and Safety of a Topical Tripeptide/Hexapeptide Anhydrous Gel When Used Pre- and Post- Hybrid Fractional Laser for the Treatment of Acne Scars |
| title_full | A Single Center, Prospective, Randomized, Blinded Study to Evaluate the Efficacy and Safety of a Topical Tripeptide/Hexapeptide Anhydrous Gel When Used Pre- and Post- Hybrid Fractional Laser for the Treatment of Acne Scars |
| title_fullStr | A Single Center, Prospective, Randomized, Blinded Study to Evaluate the Efficacy and Safety of a Topical Tripeptide/Hexapeptide Anhydrous Gel When Used Pre- and Post- Hybrid Fractional Laser for the Treatment of Acne Scars |
| title_full_unstemmed | A Single Center, Prospective, Randomized, Blinded Study to Evaluate the Efficacy and Safety of a Topical Tripeptide/Hexapeptide Anhydrous Gel When Used Pre- and Post- Hybrid Fractional Laser for the Treatment of Acne Scars |
| title_short | A Single Center, Prospective, Randomized, Blinded Study to Evaluate the Efficacy and Safety of a Topical Tripeptide/Hexapeptide Anhydrous Gel When Used Pre- and Post- Hybrid Fractional Laser for the Treatment of Acne Scars |
| title_sort | single center prospective randomized blinded study to evaluate the efficacy and safety of a topical tripeptide hexapeptide anhydrous gel when used pre and post hybrid fractional laser for the treatment of acne scars |
| topic | acne scars laser resurfacing post procedure topical |
| url | https://www.dovepress.com/a-single-center-prospective-randomized-blinded-study-to-evaluate-the-e-peer-reviewed-fulltext-article-CCID |
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