Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma
Strait et al describe distinct immune microenvironment profiles of responders versus non-responders to combined TGF-β/PD-L1 blockade in mouse models of squamous cell carcinoma (SCC). The results emphasize the potential of combined TGF-β/PD-L1 targeting and provide important clues to guide personaliz...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02522-2 |
| _version_ | 1818421210710540288 |
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| author | Alexander A. Strait Rachel A. Woolaver Spencer C. Hall Christian D. Young Sana D. Karam Antonio Jimeno Yan Lan David Raben Jing H. Wang Xiao-Jing Wang |
| author_facet | Alexander A. Strait Rachel A. Woolaver Spencer C. Hall Christian D. Young Sana D. Karam Antonio Jimeno Yan Lan David Raben Jing H. Wang Xiao-Jing Wang |
| author_sort | Alexander A. Strait |
| collection | DOAJ |
| description | Strait et al describe distinct immune microenvironment profiles of responders versus non-responders to combined TGF-β/PD-L1 blockade in mouse models of squamous cell carcinoma (SCC). The results emphasize the potential of combined TGF-β/PD-L1 targeting and provide important clues to guide personalized SCC immunotherapy. |
| first_indexed | 2024-12-14T13:06:45Z |
| format | Article |
| id | doaj.art-5bc8510595ab4074a4ee88ee8f72c43b |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T13:06:45Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-5bc8510595ab4074a4ee88ee8f72c43b2022-12-21T23:00:18ZengNature PortfolioCommunications Biology2399-36422021-08-014111510.1038/s42003-021-02522-2Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinomaAlexander A. Strait0Rachel A. Woolaver1Spencer C. Hall2Christian D. Young3Sana D. Karam4Antonio Jimeno5Yan Lan6David Raben7Jing H. Wang8Xiao-Jing Wang9Department of Pathology, University of Colorado, Anschutz Medical CampusDepartment of Immunology and Microbiology, University of Colorado, Anschutz Medical CampusDepartment of Pathology, University of Colorado, Anschutz Medical CampusDepartment of Pathology, University of Colorado, Anschutz Medical CampusDepartment of Radiation Oncology, University of Colorado, Anschutz Medical CampusDepartment of Medicine, University of Colorado, Anschutz Medical CampusEMD Serono Research and Development Institute Inc.Department of Radiation Oncology, University of Colorado, Anschutz Medical CampusDepartment of Immunology and Microbiology, University of Colorado, Anschutz Medical CampusDepartment of Pathology, University of Colorado, Anschutz Medical CampusStrait et al describe distinct immune microenvironment profiles of responders versus non-responders to combined TGF-β/PD-L1 blockade in mouse models of squamous cell carcinoma (SCC). The results emphasize the potential of combined TGF-β/PD-L1 targeting and provide important clues to guide personalized SCC immunotherapy.https://doi.org/10.1038/s42003-021-02522-2 |
| spellingShingle | Alexander A. Strait Rachel A. Woolaver Spencer C. Hall Christian D. Young Sana D. Karam Antonio Jimeno Yan Lan David Raben Jing H. Wang Xiao-Jing Wang Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma Communications Biology |
| title | Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma |
| title_full | Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma |
| title_fullStr | Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma |
| title_full_unstemmed | Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma |
| title_short | Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma |
| title_sort | distinct immune microenvironment profiles of therapeutic responders emerge in combined tgfβ pd l1 blockade treated squamous cell carcinoma |
| url | https://doi.org/10.1038/s42003-021-02522-2 |
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