PSTi8 with metformin ameliorates perimenopause induced steatohepatitis associated ER stress by regulating SIRT-1/SREBP-1c axis

PSTi8 with metformin ameliorates perimenopause induced steatohepatitis associated ER stress by regulating SIRT-1/SREBP-1c axis

Aims: Hepatic steatosis in women confronting menopause is the manifestation of substantial fructose consumption and forms a positive feedback loop to develop endoplasmic reticulum (ER) stress. Previously pancreastatin inhibitor peptide-8 (PSTi8) and Metformin (Met) combination effectively ameliorate...

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Bibliographic Details
Main Authors: Pragati Singh, Mohammad Irshad Reza, Anees A. Syed, Richa Garg, Athar Husain, Roshan Katekar, Umesh K. Goand, Mohammed Riyazuddin, Anand P. Gupta, Jiaur R. Gayen
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Heliyon
Subjects:
Combination therapy (Met + PSTi8)
PSTi8
Metformin
Hepatic steatosis
ER stress
SIRT-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020326682

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http://www.sciencedirect.com/science/article/pii/S2405844020326682

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