Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary
<p>Abstract</p> <p>Background</p> <p>Patients with cancer of unknown primary account for 10% of patients with metastatic spinal cord compression (MSCC). This retrospective study was performed to identify prognostic factors for functional outcome, local control of MSCC,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-06-01
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| Series: | BMC Cancer |
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| Online Access: | http://www.biomedcentral.com/1471-2407/12/261 |
| _version_ | 1811298967987683328 |
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| author | Douglas Sarah Huttenlocher Stefan Bajrovic Amira Rudat Volker Schild Steven E Rades Dirk |
| author_facet | Douglas Sarah Huttenlocher Stefan Bajrovic Amira Rudat Volker Schild Steven E Rades Dirk |
| author_sort | Douglas Sarah |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Patients with cancer of unknown primary account for 10% of patients with metastatic spinal cord compression (MSCC). This retrospective study was performed to identify prognostic factors for functional outcome, local control of MSCC, and survival in 175 of such patients treated with radiotherapy alone.</p> <p>Methods</p> <p>Investigated were nine potential prognostic factors including age, gender, Eastern Cooperative Oncology Group performance score (ECOG-PS), number of involved vertebrae, pre-radiotherapy ambulatory status, other bone metastases, visceral metastases, time developing motor deficits before radiotherapy, and the radiation schedule.</p> <p>Results</p> <p>On multivariate analysis, better functional outcome was associated with absence of visceral metastases (estimate: 0.72; 95%-confidence interval [CI]: 0.07-1.36; p = 0.030) and a slower (>7 days) development of motor deficits (estimate: 1.93; 95%-CI: 1.18-2.68; p < 0.001). Improved local control of MSCC was associated with absence of visceral metastases (risk ratio [RR]: 10.26; 95%-CI: 2.11-74.73; p = 0.004). Improved survival was associated with favorable ECOG-PS (RR: 2.12; 95%-CI: 1.40-3.29; p < 0.001), being ambulatory prior to radiotherapy (RR: 1.98; 95%-CI: 1.40-2.81; p < 0.001), absence of visceral metastases (RR: 2.74; 95%-CI: 1.93-3.91; p < 0.001), and slower development of motor deficits (RR: 1.27; 95%-CI: 1.07-1.51; p = 0.007). Absence of other bone metastases showed a trend (RR: 1.38; 95%-CI: 0.98-1.95; p = 0.07).</p> <p>Conclusions</p> <p>This study identified additional independent prognostic factors for functional outcome, local control of MSCC, and survival after radiotherapy of MSCC from cancer of unknown primary. These prognostic factors can help select the best treatment regimen for each individual patient.</p> |
| first_indexed | 2024-04-13T06:28:05Z |
| format | Article |
| id | doaj.art-5bcb2000c0614d53909003349c080178 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-13T06:28:05Z |
| publishDate | 2012-06-01 |
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| series | BMC Cancer |
| spelling | doaj.art-5bcb2000c0614d53909003349c0801782022-12-22T02:58:18ZengBMCBMC Cancer1471-24072012-06-0112126110.1186/1471-2407-12-261Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primaryDouglas SarahHuttenlocher StefanBajrovic AmiraRudat VolkerSchild Steven ERades Dirk<p>Abstract</p> <p>Background</p> <p>Patients with cancer of unknown primary account for 10% of patients with metastatic spinal cord compression (MSCC). This retrospective study was performed to identify prognostic factors for functional outcome, local control of MSCC, and survival in 175 of such patients treated with radiotherapy alone.</p> <p>Methods</p> <p>Investigated were nine potential prognostic factors including age, gender, Eastern Cooperative Oncology Group performance score (ECOG-PS), number of involved vertebrae, pre-radiotherapy ambulatory status, other bone metastases, visceral metastases, time developing motor deficits before radiotherapy, and the radiation schedule.</p> <p>Results</p> <p>On multivariate analysis, better functional outcome was associated with absence of visceral metastases (estimate: 0.72; 95%-confidence interval [CI]: 0.07-1.36; p = 0.030) and a slower (>7 days) development of motor deficits (estimate: 1.93; 95%-CI: 1.18-2.68; p < 0.001). Improved local control of MSCC was associated with absence of visceral metastases (risk ratio [RR]: 10.26; 95%-CI: 2.11-74.73; p = 0.004). Improved survival was associated with favorable ECOG-PS (RR: 2.12; 95%-CI: 1.40-3.29; p < 0.001), being ambulatory prior to radiotherapy (RR: 1.98; 95%-CI: 1.40-2.81; p < 0.001), absence of visceral metastases (RR: 2.74; 95%-CI: 1.93-3.91; p < 0.001), and slower development of motor deficits (RR: 1.27; 95%-CI: 1.07-1.51; p = 0.007). Absence of other bone metastases showed a trend (RR: 1.38; 95%-CI: 0.98-1.95; p = 0.07).</p> <p>Conclusions</p> <p>This study identified additional independent prognostic factors for functional outcome, local control of MSCC, and survival after radiotherapy of MSCC from cancer of unknown primary. These prognostic factors can help select the best treatment regimen for each individual patient.</p>http://www.biomedcentral.com/1471-2407/12/261Prognostic factorsCancer of unknown primaryMetastatic spinal cord compressionRadiotherapytreatment outcomes |
| spellingShingle | Douglas Sarah Huttenlocher Stefan Bajrovic Amira Rudat Volker Schild Steven E Rades Dirk Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary BMC Cancer Prognostic factors Cancer of unknown primary Metastatic spinal cord compression Radiotherapy treatment outcomes |
| title | Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary |
| title_full | Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary |
| title_fullStr | Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary |
| title_full_unstemmed | Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary |
| title_short | Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary |
| title_sort | prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary |
| topic | Prognostic factors Cancer of unknown primary Metastatic spinal cord compression Radiotherapy treatment outcomes |
| url | http://www.biomedcentral.com/1471-2407/12/261 |
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