Characterization of KRAS Mutational Regression in Oligometastatic Patients

Characterization of KRAS Mutational Regression in Oligometastatic Patients

BackgroundWe previously reported rare regressive genetic trajectories of KRAS pathogenic mutations as a specific hallmark of the genuine oligometastatic status in colorectal cancer (CRC).MethodsSurvival and prognostic impact of disease extent in 140 metastatic CRC patients were evaluated through the...

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Main Authors: Alessandro Ottaiano, Roberta Penta de Vera d’Aragona, Anna Maria Trotta, Mariachiara Santorsola, Maria Napolitano, Giosuè Scognamiglio, Fabiana Tatangelo, Paolo Grieco, Silvia Zappavigna, Vincenza Granata, Francesco Perri, Amalia Luce, Giovanni Savarese, Monica Ianniello, Marika Casillo, Nadia Petrillo, Andrea Belli, Francesco Izzo, Guglielmo Nasti, Michele Caraglia, Stefania Scala
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
oligo-metastatic disease
colorectal cancer
KRAS
cytotoxicity
HLA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.898561/full

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