PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus

PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus

Background/Aims: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine-zipper transcription factor essential for cellular responses to oxidative stress. Degradation of Nrf2 in the cytoplasm, mediated by Keap1-Cullin3/RING box1 (Cul3-Rbx1) E3 ubiquitin ligase and the proteasome, is co...

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Bibliographic Details
Main Authors:	Andrea Flores Burroughs, Sylvia Eluhu, Diva Whalen, J. Shawn Goodwin, Amos M. Sakwe, Ifeanyi J. Arinze
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Dendra2 Fluorescent protein Nrf2 Nuclear degradation Proteasome Photoconversion Cell biology Promyelocytic leukemia-nuclear bodies PyFDAP
Online Access:	https://www.karger.com/Article/FullText/490033

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