Effects of age and sex on eye movement characteristics
Abstract Abnormal eye movements are often associated with psychiatric disorders. Eye movements are sensorimotor functions of the brain, and aging and sex would affect their characteristics. A precise understanding of normal eye movements is required to distinguish disease‐related abnormalities from...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | Neuropsychopharmacology Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/npr2.12163 |
| _version_ | 1811185734403489792 |
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| author | Junichi Takahashi Kenichiro Miura Kentaro Morita Michiko Fujimoto Seiko Miyata Kosuke Okazaki Junya Matsumoto Naomi Hasegawa Yoji Hirano Hidenaga Yamamori Yuka Yasuda Manabu Makinodan Kiyoto Kasai Norio Ozaki Toshiaki Onitsuka Ryota Hashimoto |
| author_facet | Junichi Takahashi Kenichiro Miura Kentaro Morita Michiko Fujimoto Seiko Miyata Kosuke Okazaki Junya Matsumoto Naomi Hasegawa Yoji Hirano Hidenaga Yamamori Yuka Yasuda Manabu Makinodan Kiyoto Kasai Norio Ozaki Toshiaki Onitsuka Ryota Hashimoto |
| author_sort | Junichi Takahashi |
| collection | DOAJ |
| description | Abstract Abnormal eye movements are often associated with psychiatric disorders. Eye movements are sensorimotor functions of the brain, and aging and sex would affect their characteristics. A precise understanding of normal eye movements is required to distinguish disease‐related abnormalities from natural differences associated with aging or sex. To date, there is no multicohort study examining age‐related dependency and sex effects of eye movements in healthy, normal individuals using large samples to ensure the robustness and reproducibility of the results. In this study, we aimed to provide findings showing the impact of age and sex on eye movement measures. The present study used eye movement measures of more than seven hundred healthy individuals from three large independent cohorts. We herein evaluated eye movement measures quantified by using a set of standard eye movement tests that have been utilized for the examination of patients with schizophrenia. We assessed the statistical significance of the effects of age and sex and its reproducibility across cohorts. We found that 4‐18 out of 35 eye movement measures were significantly correlated with age, depending on the cohort, and that 10 of those, which are related to the fixation and motor control of smooth pursuit and saccades, showed high reproducibility. On the other hand, the effects of sex, if any, were less reproducible. The present results suggest that we should take age into account when we evaluate abnormalities in eye movements. |
| first_indexed | 2024-04-11T13:34:15Z |
| format | Article |
| id | doaj.art-5bce65e4a08240e3b7a832b8933a6da4 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-11T13:34:15Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-5bce65e4a08240e3b7a832b8933a6da42022-12-22T04:21:37ZengWileyNeuropsychopharmacology Reports2574-173X2021-06-0141215215810.1002/npr2.12163Effects of age and sex on eye movement characteristicsJunichi Takahashi0Kenichiro Miura1Kentaro Morita2Michiko Fujimoto3Seiko Miyata4Kosuke Okazaki5Junya Matsumoto6Naomi Hasegawa7Yoji Hirano8Hidenaga Yamamori9Yuka Yasuda10Manabu Makinodan11Kiyoto Kasai12Norio Ozaki13Toshiaki Onitsuka14Ryota Hashimoto15Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University Fukuoka JapanDepartment of Pathology of Mental Diseases National Institute of Mental HealthNational Center of Neurology and Psychiatry Kodaira JapanDepartment of Rehabilitation University of Tokyo Hospital Tokyo JapanDepartment of Pathology of Mental Diseases National Institute of Mental HealthNational Center of Neurology and Psychiatry Kodaira JapanDepartment of Psychiatry Graduate School of Medicine Nagoya University Nagoya JapanDepartment of Psychiatry Nara Medical University Kashihara JapanDepartment of Pathology of Mental Diseases National Institute of Mental HealthNational Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental HealthNational Center of Neurology and Psychiatry Kodaira JapanDepartment of Neuropsychiatry Graduate School of Medical Sciences Kyushu University Fukuoka JapanDepartment of Pathology of Mental Diseases National Institute of Mental HealthNational Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental HealthNational Center of Neurology and Psychiatry Kodaira JapanDepartment of Psychiatry Nara Medical University Kashihara JapanDepartment of Neuropsychiatry University of Tokyo Tokyo JapanDepartment of Psychiatry Graduate School of Medicine Nagoya University Nagoya JapanDepartment of Neuropsychiatry Graduate School of Medical Sciences Kyushu University Fukuoka JapanDepartment of Pathology of Mental Diseases National Institute of Mental HealthNational Center of Neurology and Psychiatry Kodaira JapanAbstract Abnormal eye movements are often associated with psychiatric disorders. Eye movements are sensorimotor functions of the brain, and aging and sex would affect their characteristics. A precise understanding of normal eye movements is required to distinguish disease‐related abnormalities from natural differences associated with aging or sex. To date, there is no multicohort study examining age‐related dependency and sex effects of eye movements in healthy, normal individuals using large samples to ensure the robustness and reproducibility of the results. In this study, we aimed to provide findings showing the impact of age and sex on eye movement measures. The present study used eye movement measures of more than seven hundred healthy individuals from three large independent cohorts. We herein evaluated eye movement measures quantified by using a set of standard eye movement tests that have been utilized for the examination of patients with schizophrenia. We assessed the statistical significance of the effects of age and sex and its reproducibility across cohorts. We found that 4‐18 out of 35 eye movement measures were significantly correlated with age, depending on the cohort, and that 10 of those, which are related to the fixation and motor control of smooth pursuit and saccades, showed high reproducibility. On the other hand, the effects of sex, if any, were less reproducible. The present results suggest that we should take age into account when we evaluate abnormalities in eye movements.https://doi.org/10.1002/npr2.12163ageeye movementsaccadessexsmooth pursuit |
| spellingShingle | Junichi Takahashi Kenichiro Miura Kentaro Morita Michiko Fujimoto Seiko Miyata Kosuke Okazaki Junya Matsumoto Naomi Hasegawa Yoji Hirano Hidenaga Yamamori Yuka Yasuda Manabu Makinodan Kiyoto Kasai Norio Ozaki Toshiaki Onitsuka Ryota Hashimoto Effects of age and sex on eye movement characteristics Neuropsychopharmacology Reports age eye movement saccades sex smooth pursuit |
| title | Effects of age and sex on eye movement characteristics |
| title_full | Effects of age and sex on eye movement characteristics |
| title_fullStr | Effects of age and sex on eye movement characteristics |
| title_full_unstemmed | Effects of age and sex on eye movement characteristics |
| title_short | Effects of age and sex on eye movement characteristics |
| title_sort | effects of age and sex on eye movement characteristics |
| topic | age eye movement saccades sex smooth pursuit |
| url | https://doi.org/10.1002/npr2.12163 |
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