Coating of manganese functional polyetheretherketone implants for osseous interface integration
Polyetheretherketone (PEEK) has been used extensively in biomedical engineering and it is highly desirable for PEEK implant to possess the ability to promote cell growth and significant osteogenic properties and consequently stimulate bone regeneration. In this study, a manganese modified PEEK impla...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1182187/full |
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| author | Xin Yang Shouliang Xiong Jing Zhou Yinchang Zhang Huazheng He Pingbo Chen Congming Li Qiang Wang Zhiqiang Shao Lei Wang |
| author_facet | Xin Yang Shouliang Xiong Jing Zhou Yinchang Zhang Huazheng He Pingbo Chen Congming Li Qiang Wang Zhiqiang Shao Lei Wang |
| author_sort | Xin Yang |
| collection | DOAJ |
| description | Polyetheretherketone (PEEK) has been used extensively in biomedical engineering and it is highly desirable for PEEK implant to possess the ability to promote cell growth and significant osteogenic properties and consequently stimulate bone regeneration. In this study, a manganese modified PEEK implant (PEEK-PDA-Mn) was fabricated via polydopamine chemical treatment. The results showed that manganese was successfully immobilized on PEEK surface, and the surface roughness and hydrophilicity significantly improved after surface modification. Cell experiments in vitro demonstrated that the PEEK-PDA-Mn possesses superior cytocompatibility in cell adhesion and spread. Moreover, the osteogenic properties of PEEK-PDA-Mn were proved by the increased expression of osteogenic genes, alkaline phosphatase (ALP), and mineralization in vitro. Further rat femoral condyle defect model was utilized to assess bone formation ability of different PEEK implants in vivo. The results revealed that the PEEK-PDA-Mn group promoted bone tissue regeneration in defect area. Taken together, the simple immersing method can modify the surface of PEEK, giving outstanding biocompatibility and enhanced bone tissue regeneration ability to the modified PEEK, which could be applied as an orthopedic implant in clinical. |
| first_indexed | 2024-03-13T04:19:40Z |
| format | Article |
| id | doaj.art-5bce85ad7bfb4c0494cfa7137ec31ee3 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-13T04:19:40Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-5bce85ad7bfb4c0494cfa7137ec31ee32023-06-20T13:08:31ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-05-011110.3389/fbioe.2023.11821871182187Coating of manganese functional polyetheretherketone implants for osseous interface integrationXin Yang0Shouliang Xiong1Jing Zhou2Yinchang Zhang3Huazheng He4Pingbo Chen5Congming Li6Qiang Wang7Zhiqiang Shao8Lei Wang9Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaOrthopedics and Sports Medicine Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaOrthopedics and Sports Medicine Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaPolyetheretherketone (PEEK) has been used extensively in biomedical engineering and it is highly desirable for PEEK implant to possess the ability to promote cell growth and significant osteogenic properties and consequently stimulate bone regeneration. In this study, a manganese modified PEEK implant (PEEK-PDA-Mn) was fabricated via polydopamine chemical treatment. The results showed that manganese was successfully immobilized on PEEK surface, and the surface roughness and hydrophilicity significantly improved after surface modification. Cell experiments in vitro demonstrated that the PEEK-PDA-Mn possesses superior cytocompatibility in cell adhesion and spread. Moreover, the osteogenic properties of PEEK-PDA-Mn were proved by the increased expression of osteogenic genes, alkaline phosphatase (ALP), and mineralization in vitro. Further rat femoral condyle defect model was utilized to assess bone formation ability of different PEEK implants in vivo. The results revealed that the PEEK-PDA-Mn group promoted bone tissue regeneration in defect area. Taken together, the simple immersing method can modify the surface of PEEK, giving outstanding biocompatibility and enhanced bone tissue regeneration ability to the modified PEEK, which could be applied as an orthopedic implant in clinical.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1182187/fullPEEKmanganesepolydopaminebiocompatibilityosseointegration |
| spellingShingle | Xin Yang Shouliang Xiong Jing Zhou Yinchang Zhang Huazheng He Pingbo Chen Congming Li Qiang Wang Zhiqiang Shao Lei Wang Coating of manganese functional polyetheretherketone implants for osseous interface integration Frontiers in Bioengineering and Biotechnology PEEK manganese polydopamine biocompatibility osseointegration |
| title | Coating of manganese functional polyetheretherketone implants for osseous interface integration |
| title_full | Coating of manganese functional polyetheretherketone implants for osseous interface integration |
| title_fullStr | Coating of manganese functional polyetheretherketone implants for osseous interface integration |
| title_full_unstemmed | Coating of manganese functional polyetheretherketone implants for osseous interface integration |
| title_short | Coating of manganese functional polyetheretherketone implants for osseous interface integration |
| title_sort | coating of manganese functional polyetheretherketone implants for osseous interface integration |
| topic | PEEK manganese polydopamine biocompatibility osseointegration |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1182187/full |
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