Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study
Researchers have suggested a potential relationship between gamma-glutamyl transferase (GGT) level and stroke. We investigated a potential causal relationship between GGT level as exposures and stroke and stroke subtypes (cardioembolic, small vessel, and large artery) in a European population. We pe...
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MDPI AG
2023-10-01
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| Online Access: | https://www.mdpi.com/2218-273X/13/11/1592 |
| _version_ | 1797459972235198464 |
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| author | Young Lee Je Hyun Seo |
| author_facet | Young Lee Je Hyun Seo |
| author_sort | Young Lee |
| collection | DOAJ |
| description | Researchers have suggested a potential relationship between gamma-glutamyl transferase (GGT) level and stroke. We investigated a potential causal relationship between GGT level as exposures and stroke and stroke subtypes (cardioembolic, small vessel, and large artery) in a European population. We performed a two-sample Mendelian randomization (MR) study using the genome-wide association study (GWAS) data from the UK Biobank as the exposure set. For the outcome set, we used stroke in the GWAS data from the GIGASTROKE Consortium. We considered alcohol consumption, atrial fibrillation, and body mass index as confounders. We used PhenoScanner searches for removal of SNPs and multivariable MR analysis for assessing confounders. We observed significant causal associations between GGT level and stroke (odds ratio [OR] = 1.23, 95% CI = [1.05–1.44], and <i>p</i> = 0.012 with IVW; OR = 1.19, 95% CI= [1.02–1.39], and <i>p</i> = 0.031 with MR-PRESSO). These results were consistent after removing SNPs related to confounding factors. Similarly, in multivariable MR, GGT was associated with stroke after adjusting for confounding factors (OR = 1.30, 95% CI 1.07–1.60), <i>p</i> = 0.010). Because GGT level has a causal relationship with stroke, researchers should test its significance as a potential risk factor for stroke. Additional research is required to validate these results. |
| first_indexed | 2024-03-09T16:59:25Z |
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| language | English |
| last_indexed | 2024-03-09T16:59:25Z |
| publishDate | 2023-10-01 |
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| spelling | doaj.art-5bceb5a475ba48f38097c453a32bba012023-11-24T14:31:52ZengMDPI AGBiomolecules2218-273X2023-10-011311159210.3390/biom13111592Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization StudyYoung Lee0Je Hyun Seo1Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of KoreaVeterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of KoreaResearchers have suggested a potential relationship between gamma-glutamyl transferase (GGT) level and stroke. We investigated a potential causal relationship between GGT level as exposures and stroke and stroke subtypes (cardioembolic, small vessel, and large artery) in a European population. We performed a two-sample Mendelian randomization (MR) study using the genome-wide association study (GWAS) data from the UK Biobank as the exposure set. For the outcome set, we used stroke in the GWAS data from the GIGASTROKE Consortium. We considered alcohol consumption, atrial fibrillation, and body mass index as confounders. We used PhenoScanner searches for removal of SNPs and multivariable MR analysis for assessing confounders. We observed significant causal associations between GGT level and stroke (odds ratio [OR] = 1.23, 95% CI = [1.05–1.44], and <i>p</i> = 0.012 with IVW; OR = 1.19, 95% CI= [1.02–1.39], and <i>p</i> = 0.031 with MR-PRESSO). These results were consistent after removing SNPs related to confounding factors. Similarly, in multivariable MR, GGT was associated with stroke after adjusting for confounding factors (OR = 1.30, 95% CI 1.07–1.60), <i>p</i> = 0.010). Because GGT level has a causal relationship with stroke, researchers should test its significance as a potential risk factor for stroke. Additional research is required to validate these results.https://www.mdpi.com/2218-273X/13/11/1592strokemendelian randomizationgamma-glutamyl transferasesingle-nucleotide polymorphismsalcoholatrial fibrillation |
| spellingShingle | Young Lee Je Hyun Seo Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study Biomolecules stroke mendelian randomization gamma-glutamyl transferase single-nucleotide polymorphisms alcohol atrial fibrillation |
| title | Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study |
| title_full | Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study |
| title_fullStr | Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study |
| title_full_unstemmed | Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study |
| title_short | Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study |
| title_sort | potential causal association between elevated gamma glutamyl transferase level and stroke a two sample mendelian randomization study |
| topic | stroke mendelian randomization gamma-glutamyl transferase single-nucleotide polymorphisms alcohol atrial fibrillation |
| url | https://www.mdpi.com/2218-273X/13/11/1592 |
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