Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus
BackgroundThe prevalence of diabetes is on the rise globally coupled with its associated complications, such as diabetic nephropathy (DN). Obesity has been identified as a risk factor for the development of DN but it is still unclear which obesity index is the best predictor of incident DN.MethodsDa...
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.706845/full |
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| author | Daniel Nyarko Hukportie Fu-Rong Li Fu-Rong Li Rui Zhou Jia-Zhen Zheng Xiao-Xiang Wu Xian-Bo Wu |
| author_facet | Daniel Nyarko Hukportie Fu-Rong Li Fu-Rong Li Rui Zhou Jia-Zhen Zheng Xiao-Xiang Wu Xian-Bo Wu |
| author_sort | Daniel Nyarko Hukportie |
| collection | DOAJ |
| description | BackgroundThe prevalence of diabetes is on the rise globally coupled with its associated complications, such as diabetic nephropathy (DN). Obesity has been identified as a risk factor for the development of DN but it is still unclear which obesity index is the best predictor of incident DN.MethodsData from the participants with type 2 diabetes mellitus (T2DM) in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study were used to examine the sex-specific association between waist circumference (WC), waist-to-height ratio (WHtR), and body mass index (BMI) with incident DN risk.ResultsAmong the 8,887 participants with T2DM (5,489 men and 3,398 women), 5,296 participants (3,345 men and 1,951 women) developed the DN composite outcome during a follow-up period of 24302 person-years. Among men, null associations were observed between all anthropometric measures with incident DN in the multivariate analysis although the 3rd quartile of WHtR showed marginally significant results (P = 0.052). However, among women, both central and general obesity measures were associated with increased risks of incident DN. Compared with participants in the WC <88 cm category, the fully adjusted HR and 95% CI for those in the ≥88 cm of WC was 1.35 (95% CI 1.15-1.57). Compared with the lowest quartile, the fully adjusted HRs and 95% CIs for the 2nd to the 4th quartile of WHtR were 1.09 (95% CI 0.96-1.25), 1.12 (95% CI 0.98-1.28), and 1.14 (95% CI 1.00-1.30) respectively; also, compared with the normal BMI category, the fully adjusted HRs and 95% CIs for class I – class III obese were 1.36 (95% CI 1.10 – 1.67), 1.43 (95% CI 1.16 – 1.78) and 1.32 (95% CI 1.05 – 1.66) respectively.ConclusionsAmong participants with T2DM, higher levels of both central and general obesity indexes were associated with DN risk among women but not in men. Women with T2DM should maintain a healthy weight targeted at reducing both central and general obesity to enhance nephroprotection. Trial registration: ClinicalTrials.gov., no. NCT00000620. |
| first_indexed | 2024-12-13T19:56:54Z |
| format | Article |
| id | doaj.art-5bcf0cff656a4d51a5379f48a75c832c |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-13T19:56:54Z |
| publishDate | 2021-08-01 |
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| spelling | doaj.art-5bcf0cff656a4d51a5379f48a75c832c2022-12-21T23:33:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-08-011210.3389/fendo.2021.706845706845Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes MellitusDaniel Nyarko Hukportie0Fu-Rong Li1Fu-Rong Li2Rui Zhou3Jia-Zhen Zheng4Xiao-Xiang Wu5Xian-Bo Wu6Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, ChinaDepartment of General Surgery, 157th Hospital, General Hospital of Guangzhou Military Command, Guangzhou, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, ChinaBackgroundThe prevalence of diabetes is on the rise globally coupled with its associated complications, such as diabetic nephropathy (DN). Obesity has been identified as a risk factor for the development of DN but it is still unclear which obesity index is the best predictor of incident DN.MethodsData from the participants with type 2 diabetes mellitus (T2DM) in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study were used to examine the sex-specific association between waist circumference (WC), waist-to-height ratio (WHtR), and body mass index (BMI) with incident DN risk.ResultsAmong the 8,887 participants with T2DM (5,489 men and 3,398 women), 5,296 participants (3,345 men and 1,951 women) developed the DN composite outcome during a follow-up period of 24302 person-years. Among men, null associations were observed between all anthropometric measures with incident DN in the multivariate analysis although the 3rd quartile of WHtR showed marginally significant results (P = 0.052). However, among women, both central and general obesity measures were associated with increased risks of incident DN. Compared with participants in the WC <88 cm category, the fully adjusted HR and 95% CI for those in the ≥88 cm of WC was 1.35 (95% CI 1.15-1.57). Compared with the lowest quartile, the fully adjusted HRs and 95% CIs for the 2nd to the 4th quartile of WHtR were 1.09 (95% CI 0.96-1.25), 1.12 (95% CI 0.98-1.28), and 1.14 (95% CI 1.00-1.30) respectively; also, compared with the normal BMI category, the fully adjusted HRs and 95% CIs for class I – class III obese were 1.36 (95% CI 1.10 – 1.67), 1.43 (95% CI 1.16 – 1.78) and 1.32 (95% CI 1.05 – 1.66) respectively.ConclusionsAmong participants with T2DM, higher levels of both central and general obesity indexes were associated with DN risk among women but not in men. Women with T2DM should maintain a healthy weight targeted at reducing both central and general obesity to enhance nephroprotection. Trial registration: ClinicalTrials.gov., no. NCT00000620.https://www.frontiersin.org/articles/10.3389/fendo.2021.706845/fullobesitywaist circumferencewaist-to-height ratiobody mass indexdiabetic nephropathy |
| spellingShingle | Daniel Nyarko Hukportie Fu-Rong Li Fu-Rong Li Rui Zhou Jia-Zhen Zheng Xiao-Xiang Wu Xian-Bo Wu Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus Frontiers in Endocrinology obesity waist circumference waist-to-height ratio body mass index diabetic nephropathy |
| title | Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus |
| title_full | Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus |
| title_fullStr | Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus |
| title_full_unstemmed | Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus |
| title_short | Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus |
| title_sort | anthropometric measures and incident diabetic nephropathy in participants with type 2 diabetes mellitus |
| topic | obesity waist circumference waist-to-height ratio body mass index diabetic nephropathy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.706845/full |
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