Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy?
Gene therapy holds great promise for curing cancer by editing the deleterious genes of tumor cells, but the lack of vector systems for efficient delivery of genetic material into specific tumor sites in vivo has limited its full therapeutic potential in cancer gene therapy. Over the past two decades...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304222000800 |
| _version_ | 1827267278739079168 |
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| author | Longfei Deng Ping Liang Hongjuan Cui |
| author_facet | Longfei Deng Ping Liang Hongjuan Cui |
| author_sort | Longfei Deng |
| collection | DOAJ |
| description | Gene therapy holds great promise for curing cancer by editing the deleterious genes of tumor cells, but the lack of vector systems for efficient delivery of genetic material into specific tumor sites in vivo has limited its full therapeutic potential in cancer gene therapy. Over the past two decades, increasing studies have shown that lentiviral vectors (LVs) modified with different glycoproteins from a donating virus, a process referred to as pseudotyping, have altered tropism and display cell-type specificity in transduction, leading to selective tumor cell killing. This feature of LVs together with their ability to enable high efficient gene delivery in dividing and non-dividing mammalian cells in vivo make them to be attractive tools in future cancer gene therapy. This review is intended to summarize the status quo of some typical pseudotypings of LVs and their applications in basic anti-cancer studies across many malignancies. The opportunities of translating pseudotyped LVs into clinic use in cancer therapy have also been discussed. |
| first_indexed | 2024-03-13T00:14:26Z |
| format | Article |
| id | doaj.art-5bd188a5b7134c428d10a28a1b4704cf |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T04:31:12Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-5bd188a5b7134c428d10a28a1b4704cf2024-04-28T03:19:29ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422023-09-0110519371955Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy?Longfei Deng0Ping Liang1Hongjuan Cui2Cancer Center, Medical Research Institute, Southwest University, Chongqing 400716, ChinaDepartment of Neurosurgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China; Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China; Corresponding author. Department of Neurosurgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.Cancer Center, Medical Research Institute, Southwest University, Chongqing 400716, China; State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China; Corresponding author. Cancer Center, Medical Research Institute, Southwest University, Chongqing 400716, China.Gene therapy holds great promise for curing cancer by editing the deleterious genes of tumor cells, but the lack of vector systems for efficient delivery of genetic material into specific tumor sites in vivo has limited its full therapeutic potential in cancer gene therapy. Over the past two decades, increasing studies have shown that lentiviral vectors (LVs) modified with different glycoproteins from a donating virus, a process referred to as pseudotyping, have altered tropism and display cell-type specificity in transduction, leading to selective tumor cell killing. This feature of LVs together with their ability to enable high efficient gene delivery in dividing and non-dividing mammalian cells in vivo make them to be attractive tools in future cancer gene therapy. This review is intended to summarize the status quo of some typical pseudotypings of LVs and their applications in basic anti-cancer studies across many malignancies. The opportunities of translating pseudotyped LVs into clinic use in cancer therapy have also been discussed.http://www.sciencedirect.com/science/article/pii/S2352304222000800Cancer therapyClinical translationGene deliveryLentiviral vectorPseudotype |
| spellingShingle | Longfei Deng Ping Liang Hongjuan Cui Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? Genes and Diseases Cancer therapy Clinical translation Gene delivery Lentiviral vector Pseudotype |
| title | Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
| title_full | Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
| title_fullStr | Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
| title_full_unstemmed | Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
| title_short | Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
| title_sort | pseudotyped lentiviral vectors ready for translation into targeted cancer gene therapy |
| topic | Cancer therapy Clinical translation Gene delivery Lentiviral vector Pseudotype |
| url | http://www.sciencedirect.com/science/article/pii/S2352304222000800 |
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