A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection
Abstract Background High early morbidity and mortality following antiretroviral therapy (ART) initiation has been a distinguishing feature of ART programmes in resource limited settings (RLS) compared to high-income countries. This study assessed how well body mass index (BMI: kg/m2) correlated with...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | Infectious Diseases of Poverty |
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| Online Access: | http://link.springer.com/article/10.1186/s40249-018-0418-3 |
| _version_ | 1818029526380183552 |
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| author | Kogieleum Naidoo Nonhlanhla Yende-Zuma Stanton Augustine |
| author_facet | Kogieleum Naidoo Nonhlanhla Yende-Zuma Stanton Augustine |
| author_sort | Kogieleum Naidoo |
| collection | DOAJ |
| description | Abstract Background High early morbidity and mortality following antiretroviral therapy (ART) initiation has been a distinguishing feature of ART programmes in resource limited settings (RLS) compared to high-income countries. This study assessed how well body mass index (BMI: kg/m2) correlated with survival among HIV infected patients with and without TB co-infection. Methods We retrospectively evaluated clinical data from 1000 HIV infected patients, among whom 389 were also co-infected with TB, between January 2008 and December 2010, in KwaZulu-Natal, South Africa. Results Among 948 patients eligible for analysis, 15.7% (149/948) were underweight (< 18.50), 55.9% (530/948) had normal BMI (≥18.50–24.90), 18.7% (177/948) were overweight (25.00–29.00) and 9.7% (92/948) were obese (≥30.00). Irrespective of TB status, underweight patients, had significantly higher risk of death compared to those with normal BMI at baseline (aHR = 2.9; 95% CI: 1.5–5.7; P = 0.002). Conclusions Irrespective of TB co-infection, low BMI correlated with mortality in HIV infected patients. Trial registration UKZN Biomedical Research Ethics Committee Reference number E 248/05, 23 September 2005. |
| first_indexed | 2024-12-10T05:21:05Z |
| format | Article |
| id | doaj.art-5bd34afda98e4358b4d08b5d75598dd8 |
| institution | Directory Open Access Journal |
| issn | 2049-9957 |
| language | English |
| last_indexed | 2024-12-10T05:21:05Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Diseases of Poverty |
| spelling | doaj.art-5bd34afda98e4358b4d08b5d75598dd82022-12-22T02:00:48ZengBMCInfectious Diseases of Poverty2049-99572018-04-01711610.1186/s40249-018-0418-3A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infectionKogieleum Naidoo0Nonhlanhla Yende-Zuma1Stanton Augustine2Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-NatalCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-NatalCentre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-NatalAbstract Background High early morbidity and mortality following antiretroviral therapy (ART) initiation has been a distinguishing feature of ART programmes in resource limited settings (RLS) compared to high-income countries. This study assessed how well body mass index (BMI: kg/m2) correlated with survival among HIV infected patients with and without TB co-infection. Methods We retrospectively evaluated clinical data from 1000 HIV infected patients, among whom 389 were also co-infected with TB, between January 2008 and December 2010, in KwaZulu-Natal, South Africa. Results Among 948 patients eligible for analysis, 15.7% (149/948) were underweight (< 18.50), 55.9% (530/948) had normal BMI (≥18.50–24.90), 18.7% (177/948) were overweight (25.00–29.00) and 9.7% (92/948) were obese (≥30.00). Irrespective of TB status, underweight patients, had significantly higher risk of death compared to those with normal BMI at baseline (aHR = 2.9; 95% CI: 1.5–5.7; P = 0.002). Conclusions Irrespective of TB co-infection, low BMI correlated with mortality in HIV infected patients. Trial registration UKZN Biomedical Research Ethics Committee Reference number E 248/05, 23 September 2005.http://link.springer.com/article/10.1186/s40249-018-0418-3HIVTuberculosisBMIARTAfricaKwaZulu-Natal |
| spellingShingle | Kogieleum Naidoo Nonhlanhla Yende-Zuma Stanton Augustine A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection Infectious Diseases of Poverty HIV Tuberculosis BMI ART Africa KwaZulu-Natal |
| title | A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection |
| title_full | A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection |
| title_fullStr | A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection |
| title_full_unstemmed | A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection |
| title_short | A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection |
| title_sort | retrospective cohort study of body mass index and survival in hiv infected patients with and without tb co infection |
| topic | HIV Tuberculosis BMI ART Africa KwaZulu-Natal |
| url | http://link.springer.com/article/10.1186/s40249-018-0418-3 |
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