ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITRO
Galing plant (Cayratia trifolia L. Domin) is a wild plant that spreads and is easily found in Indonesia, especially in the lowlands, which contains a class of secondary metabolites such as flavonoids, polyphenols, alkaloids, terpenoids, and triterpenoids with various pharmacological activities such...
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| Format: | Article |
| Language: | Indonesian |
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Universitas Muhammadiyah Magelang
2022-01-01
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| Series: | Jurnal Farmasi Sains dan Praktis |
| Subjects: | |
| Online Access: | http://journal.unimma.ac.id/index.php/pharmacy/article/view/6107 |
| _version_ | 1818298448151052288 |
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| author | Muhammad Ilyas Y Muhammad Syaiful Saehu Ertin _ Irma _ Nurhikma _ |
| author_facet | Muhammad Ilyas Y Muhammad Syaiful Saehu Ertin _ Irma _ Nurhikma _ |
| author_sort | Muhammad Ilyas Y |
| collection | DOAJ |
| description | Galing plant (Cayratia trifolia L. Domin) is a wild plant that spreads and is easily found in Indonesia, especially in the lowlands, which contains a class of secondary metabolites such as flavonoids, polyphenols, alkaloids, terpenoids, and triterpenoids with various pharmacological activities such as antidiabetic, immunomodulatory, antibacterial, anti-fungal, anti-diarrhea, gout. This study aims to determine the antiinflammatory effect of several fractions of rod galing using the in vitro model of red blood cell membrane stabilization. This study used an ethanol extract fractionated in a liquid-liquid manner with n-hexane, ethyl acetate, and water as a solvent. Then, the anti-inflammatory effect of each fraction was tested, with a positive control comparison of diclofenac sodium with varying concentrations. Measurement of anti-inflammatory activity was calculated based on the % stability of the red blood cell membrane. The results showed that the ethyl acetate, n-hexane and water fractions from the ethanol extract of galing (Cayratia trifolia L. Domin.) stem had an anti-inflammatory effect based on the % stability of red blood cell membranes, where the ethyl acetate fraction with a concentration of 1000 ppm had the best anti-inflammatory effect with % stability of red blood cell membranes was 91.81%, which was significantly different from the positive control (p<0.05). |
| first_indexed | 2024-12-13T04:35:29Z |
| format | Article |
| id | doaj.art-5bd4008afecf4f90aee25780f3e45cba |
| institution | Directory Open Access Journal |
| issn | 2549-9068 2579-4558 |
| language | Indonesian |
| last_indexed | 2024-12-13T04:35:29Z |
| publishDate | 2022-01-01 |
| publisher | Universitas Muhammadiyah Magelang |
| record_format | Article |
| series | Jurnal Farmasi Sains dan Praktis |
| spelling | doaj.art-5bd4008afecf4f90aee25780f3e45cba2022-12-21T23:59:26ZindUniversitas Muhammadiyah MagelangJurnal Farmasi Sains dan Praktis2549-90682579-45582022-01-0110.31603/pharmacy.v1i1.6107ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITROMuhammad Ilyas Y0Muhammad Syaiful Saehu1Ertin _2Irma _3Nurhikma _4Politeknik Bina Husada Kendari dan Fakultas Farmasi Universitas Halu Oleo KendariPoliteknik Bina Husada Kendari, KendariPoliteknik Bina Husada Kendari, KendariFakultas Kesehatan Masyarakat Universitas Halu Oleo, KendariInstalasi Farmasi Rumah Sakit Umum Daerah Bahteramas, KendariGaling plant (Cayratia trifolia L. Domin) is a wild plant that spreads and is easily found in Indonesia, especially in the lowlands, which contains a class of secondary metabolites such as flavonoids, polyphenols, alkaloids, terpenoids, and triterpenoids with various pharmacological activities such as antidiabetic, immunomodulatory, antibacterial, anti-fungal, anti-diarrhea, gout. This study aims to determine the antiinflammatory effect of several fractions of rod galing using the in vitro model of red blood cell membrane stabilization. This study used an ethanol extract fractionated in a liquid-liquid manner with n-hexane, ethyl acetate, and water as a solvent. Then, the anti-inflammatory effect of each fraction was tested, with a positive control comparison of diclofenac sodium with varying concentrations. Measurement of anti-inflammatory activity was calculated based on the % stability of the red blood cell membrane. The results showed that the ethyl acetate, n-hexane and water fractions from the ethanol extract of galing (Cayratia trifolia L. Domin.) stem had an anti-inflammatory effect based on the % stability of red blood cell membranes, where the ethyl acetate fraction with a concentration of 1000 ppm had the best anti-inflammatory effect with % stability of red blood cell membranes was 91.81%, which was significantly different from the positive control (p<0.05).http://journal.unimma.ac.id/index.php/pharmacy/article/view/6107Cayratia trifolia L. DominFractionAntiinflammatoryRed blood cellsIn vitro |
| spellingShingle | Muhammad Ilyas Y Muhammad Syaiful Saehu Ertin _ Irma _ Nurhikma _ ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITRO Jurnal Farmasi Sains dan Praktis Cayratia trifolia L. Domin Fraction Antiinflammatory Red blood cells In vitro |
| title | ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITRO |
| title_full | ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITRO |
| title_fullStr | ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITRO |
| title_full_unstemmed | ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITRO |
| title_short | ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITRO |
| title_sort | antiinflammatory effects of fraction from galing stem ethanol extract cayratia trifolia l domin in vitro |
| topic | Cayratia trifolia L. Domin Fraction Antiinflammatory Red blood cells In vitro |
| url | http://journal.unimma.ac.id/index.php/pharmacy/article/view/6107 |
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