Influence of fetal tissues transplantation on the brain serotoninergic systems in experimental animals after traumatic brain injury

Introduction. Taking into consideration the high frequency of complications after severe traumatic brain injury (STBI), caused mainly by different brain neuromediator systems integrative disfunctions, a search of methods for their correction is the actual task of neurotraumatology.Materia...

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Main Authors: Boris Baranenko, Vitaliy Tsymbaliuk, Irina Vasileva, Nataliya Chopik
Format: Article
Language:English
Published: Romodanov Neurosurgery Institute 2012-06-01
Series:Ukrainian Neurosurgical Journal
Online Access:https://theunj.org/article/view/59043
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author Boris Baranenko
Vitaliy Tsymbaliuk
Irina Vasileva
Nataliya Chopik
author_facet Boris Baranenko
Vitaliy Tsymbaliuk
Irina Vasileva
Nataliya Chopik
author_sort Boris Baranenko
collection DOAJ
description Introduction. Taking into consideration the high frequency of complications after severe traumatic brain injury (STBI), caused mainly by different brain neuromediator systems integrative disfunctions, a search of methods for their correction is the actual task of neurotraumatology.Materials and methods. We investigated serotonin and its’ metabolite — 5-hydroxyindolylacetic acid (5-HIAA) levels in structures of brain of experimental animals after STBI, and also influence of fetal nervous (FNT) and fetal muscular (FMT) tissues transplantation on these indexes using high performative method of liquid chromatography.Results. It was found that serotonin and 5-HIAA levels in the cortex of left (damaged) hemisphere significantly decreased and 30 days after trauma in the hypothalamus of experimental animals serotonin level decreased, but level of 5-HIAA increased. In animals, in which in 2 hours after STBI FNT was transplanted, 5-HIAA level was within a reference level, while serotonin level considerably decreased.Conclusions. FNT transplantation has the stimulating influence on indolamines’ metabolism, but does not result in complete renewing of serotonin level in some structures of the brain 30 days after STBI. FMT transplantation has strong stimulating influence on the level of serotonin in experimental animals’ brain, testifying to it’s generalized trophic influence on the serotoninergic neurons.
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spelling doaj.art-5bd5f68ec6f6497db6651274198ea0ea2024-01-27T08:08:46ZengRomodanov Neurosurgery InstituteUkrainian Neurosurgical Journal2663-90842663-90922012-06-012182310.25305/unj.59043Influence of fetal tissues transplantation on the brain serotoninergic systems in experimental animals after traumatic brain injuryBoris Baranenko0Vitaliy Tsymbaliuk1https://orcid.org/0000-0001-7544-6603Irina Vasileva2Nataliya Chopik3Romodanov Neurosurgery Institute, Kiev, UkraineRomodanov Neurosurgery Institute, Kiev, UkraineRomodanov Neurosurgery Institute, Kiev, UkraineRomodanov Neurosurgery Institute, Kiev, Ukraine Introduction. Taking into consideration the high frequency of complications after severe traumatic brain injury (STBI), caused mainly by different brain neuromediator systems integrative disfunctions, a search of methods for their correction is the actual task of neurotraumatology.Materials and methods. We investigated serotonin and its’ metabolite — 5-hydroxyindolylacetic acid (5-HIAA) levels in structures of brain of experimental animals after STBI, and also influence of fetal nervous (FNT) and fetal muscular (FMT) tissues transplantation on these indexes using high performative method of liquid chromatography.Results. It was found that serotonin and 5-HIAA levels in the cortex of left (damaged) hemisphere significantly decreased and 30 days after trauma in the hypothalamus of experimental animals serotonin level decreased, but level of 5-HIAA increased. In animals, in which in 2 hours after STBI FNT was transplanted, 5-HIAA level was within a reference level, while serotonin level considerably decreased.Conclusions. FNT transplantation has the stimulating influence on indolamines’ metabolism, but does not result in complete renewing of serotonin level in some structures of the brain 30 days after STBI. FMT transplantation has strong stimulating influence on the level of serotonin in experimental animals’ brain, testifying to it’s generalized trophic influence on the serotoninergic neurons.https://theunj.org/article/view/59043
spellingShingle Boris Baranenko
Vitaliy Tsymbaliuk
Irina Vasileva
Nataliya Chopik
Influence of fetal tissues transplantation on the brain serotoninergic systems in experimental animals after traumatic brain injury
Ukrainian Neurosurgical Journal
title Influence of fetal tissues transplantation on the brain serotoninergic systems in experimental animals after traumatic brain injury
title_full Influence of fetal tissues transplantation on the brain serotoninergic systems in experimental animals after traumatic brain injury
title_fullStr Influence of fetal tissues transplantation on the brain serotoninergic systems in experimental animals after traumatic brain injury
title_full_unstemmed Influence of fetal tissues transplantation on the brain serotoninergic systems in experimental animals after traumatic brain injury
title_short Influence of fetal tissues transplantation on the brain serotoninergic systems in experimental animals after traumatic brain injury
title_sort influence of fetal tissues transplantation on the brain serotoninergic systems in experimental animals after traumatic brain injury
url https://theunj.org/article/view/59043
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