Vascular endothelial growth factor C (<it>VEGF-C</it>) in esophageal cancer correlates with lymph node metastasis and poor patient prognosis
<p>Abstract</p> <p>Background</p> <p>The diagnosis of lymph node metastasis in esophageal cancer by the presence and number of metastatic lymph nodes is an extremely important prognostic factor. In addition, the indication of non-surgical therapy is gaining more attenti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-06-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Online Access: | http://www.jeccr.com/content/29/1/83 |
| _version_ | 1818062780406693888 |
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| author | Naganawa Yasuhiro Shiozaki Midori Katada Takeyasu Mitsui Akira Kimura Masahiro Kuwabara Yoshiyuki Ishiguro Hideyuki Tanaka Tatsuya Fujii Yoshitaka Takeyama Hiromitsu |
| author_facet | Naganawa Yasuhiro Shiozaki Midori Katada Takeyasu Mitsui Akira Kimura Masahiro Kuwabara Yoshiyuki Ishiguro Hideyuki Tanaka Tatsuya Fujii Yoshitaka Takeyama Hiromitsu |
| author_sort | Naganawa Yasuhiro |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The diagnosis of lymph node metastasis in esophageal cancer by the presence and number of metastatic lymph nodes is an extremely important prognostic factor. In addition, the indication of non-surgical therapy is gaining more attention. Vascular endothelial growth factor C (VEGF-C) is potentially lymphangiogenic and selectively induces hyperplasia of the lymphatic vasculature. In this study, we investigated the expression of <it>VEGF-C </it>and whether it correlated with various clinico-pathologic findings.</p> <p>Methods</p> <p>KYSE series of esophageal cancer cell lines and 106 patients with primary esophageal squamous cell carcinomas who had undergone radical esophagectomy were analyzed. <it>VEGF-C </it>mRNA expression was determined by quantitative RT-PCR.</p> <p>Results</p> <p>High expression of <it>VEGF-C </it>was detected in most of the KYSE cell lines, especially KYSE410, yet, in an esophageal normal epithelium cell line, Het-1A, <it>VEGF-C </it>was not detected. In the clinical specimen, the expression of <it>VEGF-C </it>in the cancerous tissue was higher than in the corresponding noncancerous esophageal mucosa (p = 0.026). The expression of <it>VEGF-C </it>was found to be higher in Stage2B-4A tumors than in Stage0-2A tumors (p = 0.049). When the patients were divided into two groups according to their expression levels of <it>VEGF-C </it>(a group of 53 cases with high expression and a group of 53 cases with low expression), the patients with high <it>VEGF-C </it>expression had significantly shorter survival after surgery than the patients with low expression (p = 0.0065). Although univariate analysis showed that high expression of <it>VEGF-C </it>was a statistically significant prognostic factor, this was not shown in multivariate analysis. In the subgroup of patients with Tis and T1 tumors, the expression of <it>VEGF-C </it>was higher in N1 tumors than in N0 tumors (p = 0.029). The survival rate of patients from the high expression group (n = 10) was lower than that in the low expression group (n = 11), and all the patients in the low VEGF-C expression group survived.</p> <p>Conclusions</p> <p>The expression of <it>VEGF-C </it>correlates with lymph node metastasis and poor prognosis. In patients with Tis and T1 esophageal tumors, the expression of VEGF-C may be a good diagnostic factor for determining metastasis of the lymph node.</p> |
| first_indexed | 2024-12-10T14:09:39Z |
| format | Article |
| id | doaj.art-5bd8c98fe05e4809bd470e95f1ab5316 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
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| publishDate | 2010-06-01 |
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| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-5bd8c98fe05e4809bd470e95f1ab53162022-12-22T01:45:33ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662010-06-012918310.1186/1756-9966-29-83Vascular endothelial growth factor C (<it>VEGF-C</it>) in esophageal cancer correlates with lymph node metastasis and poor patient prognosisNaganawa YasuhiroShiozaki MidoriKatada TakeyasuMitsui AkiraKimura MasahiroKuwabara YoshiyukiIshiguro HideyukiTanaka TatsuyaFujii YoshitakaTakeyama Hiromitsu<p>Abstract</p> <p>Background</p> <p>The diagnosis of lymph node metastasis in esophageal cancer by the presence and number of metastatic lymph nodes is an extremely important prognostic factor. In addition, the indication of non-surgical therapy is gaining more attention. Vascular endothelial growth factor C (VEGF-C) is potentially lymphangiogenic and selectively induces hyperplasia of the lymphatic vasculature. In this study, we investigated the expression of <it>VEGF-C </it>and whether it correlated with various clinico-pathologic findings.</p> <p>Methods</p> <p>KYSE series of esophageal cancer cell lines and 106 patients with primary esophageal squamous cell carcinomas who had undergone radical esophagectomy were analyzed. <it>VEGF-C </it>mRNA expression was determined by quantitative RT-PCR.</p> <p>Results</p> <p>High expression of <it>VEGF-C </it>was detected in most of the KYSE cell lines, especially KYSE410, yet, in an esophageal normal epithelium cell line, Het-1A, <it>VEGF-C </it>was not detected. In the clinical specimen, the expression of <it>VEGF-C </it>in the cancerous tissue was higher than in the corresponding noncancerous esophageal mucosa (p = 0.026). The expression of <it>VEGF-C </it>was found to be higher in Stage2B-4A tumors than in Stage0-2A tumors (p = 0.049). When the patients were divided into two groups according to their expression levels of <it>VEGF-C </it>(a group of 53 cases with high expression and a group of 53 cases with low expression), the patients with high <it>VEGF-C </it>expression had significantly shorter survival after surgery than the patients with low expression (p = 0.0065). Although univariate analysis showed that high expression of <it>VEGF-C </it>was a statistically significant prognostic factor, this was not shown in multivariate analysis. In the subgroup of patients with Tis and T1 tumors, the expression of <it>VEGF-C </it>was higher in N1 tumors than in N0 tumors (p = 0.029). The survival rate of patients from the high expression group (n = 10) was lower than that in the low expression group (n = 11), and all the patients in the low VEGF-C expression group survived.</p> <p>Conclusions</p> <p>The expression of <it>VEGF-C </it>correlates with lymph node metastasis and poor prognosis. In patients with Tis and T1 esophageal tumors, the expression of VEGF-C may be a good diagnostic factor for determining metastasis of the lymph node.</p>http://www.jeccr.com/content/29/1/83 |
| spellingShingle | Naganawa Yasuhiro Shiozaki Midori Katada Takeyasu Mitsui Akira Kimura Masahiro Kuwabara Yoshiyuki Ishiguro Hideyuki Tanaka Tatsuya Fujii Yoshitaka Takeyama Hiromitsu Vascular endothelial growth factor C (<it>VEGF-C</it>) in esophageal cancer correlates with lymph node metastasis and poor patient prognosis Journal of Experimental & Clinical Cancer Research |
| title | Vascular endothelial growth factor C (<it>VEGF-C</it>) in esophageal cancer correlates with lymph node metastasis and poor patient prognosis |
| title_full | Vascular endothelial growth factor C (<it>VEGF-C</it>) in esophageal cancer correlates with lymph node metastasis and poor patient prognosis |
| title_fullStr | Vascular endothelial growth factor C (<it>VEGF-C</it>) in esophageal cancer correlates with lymph node metastasis and poor patient prognosis |
| title_full_unstemmed | Vascular endothelial growth factor C (<it>VEGF-C</it>) in esophageal cancer correlates with lymph node metastasis and poor patient prognosis |
| title_short | Vascular endothelial growth factor C (<it>VEGF-C</it>) in esophageal cancer correlates with lymph node metastasis and poor patient prognosis |
| title_sort | vascular endothelial growth factor c it vegf c it in esophageal cancer correlates with lymph node metastasis and poor patient prognosis |
| url | http://www.jeccr.com/content/29/1/83 |
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