Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine
Wakefulness is defined as a state in which individuals can react to a change in situations. The number of people staying awake and compensating for lack of sleep has increased in recent years. Caffeine, a representative stimulant, is the most extensively consumed compound globally and is mainly cons...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/4/1042 |
| _version_ | 1797618883521150976 |
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| author | Duhyeon Kim Seonghui Kim Minseok Yoon Min Young Um Suengmok Cho |
| author_facet | Duhyeon Kim Seonghui Kim Minseok Yoon Min Young Um Suengmok Cho |
| author_sort | Duhyeon Kim |
| collection | DOAJ |
| description | Wakefulness is defined as a state in which individuals can react to a change in situations. The number of people staying awake and compensating for lack of sleep has increased in recent years. Caffeine, a representative stimulant, is the most extensively consumed compound globally and is mainly consumed through coffee. Although green tea (<i>Camellia sinensis</i> L.) contains high caffeine content like coffee, its arousal-inducing effects have not yet been studied. In the present study, we aimed to identify the arousal-inducing effect of GT during a chronic administration period (three weeks) using analysis of sleep architecture. Treatment with GT (1500 mg/kg) significantly elevated the sleep latency and wakefulness throughout the treatment period, and chronic administration of GT consistently maintained an increase in wakefulness for up to 3 h. During the treatment period, the arousal-inducing effect of GT (1500 mg/kg) occurred without any change in the tolerance phenomenon or withdrawal symptoms, similar to that observed with caffeine (25 mg/kg). GT (1500 mg/kg) containing 95.6 mg/kg of caffeine did not produce a better arousal-inducing effect than caffeine at 25 mg/kg. These results indicate that the arousal-inducing effect of GT persisted for three weeks without adverse effects and that GT can control the arousal-inducing effects of caffeine due to the hypnotic effects of its other constituents. |
| first_indexed | 2024-03-11T08:18:53Z |
| format | Article |
| id | doaj.art-5bd9561c3a8a45fbab6ad744a84d9bdb |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T08:18:53Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-5bd9561c3a8a45fbab6ad744a84d9bdb2023-11-16T22:32:26ZengMDPI AGNutrients2072-66432023-02-01154104210.3390/nu15041042Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant CaffeineDuhyeon Kim0Seonghui Kim1Minseok Yoon2Min Young Um3Suengmok Cho4Department of Food Science and Technology, Institute of Food Science, Pukyong National University, Busan 48513, Republic of KoreaDepartment of Food Science and Technology, Institute of Food Science, Pukyong National University, Busan 48513, Republic of KoreaResearch Division of Food Functionality, Korea Food Research Institute, Wanju 55365, Republic of KoreaResearch Division of Food Functionality, Korea Food Research Institute, Wanju 55365, Republic of KoreaDepartment of Food Science and Technology, Institute of Food Science, Pukyong National University, Busan 48513, Republic of KoreaWakefulness is defined as a state in which individuals can react to a change in situations. The number of people staying awake and compensating for lack of sleep has increased in recent years. Caffeine, a representative stimulant, is the most extensively consumed compound globally and is mainly consumed through coffee. Although green tea (<i>Camellia sinensis</i> L.) contains high caffeine content like coffee, its arousal-inducing effects have not yet been studied. In the present study, we aimed to identify the arousal-inducing effect of GT during a chronic administration period (three weeks) using analysis of sleep architecture. Treatment with GT (1500 mg/kg) significantly elevated the sleep latency and wakefulness throughout the treatment period, and chronic administration of GT consistently maintained an increase in wakefulness for up to 3 h. During the treatment period, the arousal-inducing effect of GT (1500 mg/kg) occurred without any change in the tolerance phenomenon or withdrawal symptoms, similar to that observed with caffeine (25 mg/kg). GT (1500 mg/kg) containing 95.6 mg/kg of caffeine did not produce a better arousal-inducing effect than caffeine at 25 mg/kg. These results indicate that the arousal-inducing effect of GT persisted for three weeks without adverse effects and that GT can control the arousal-inducing effects of caffeine due to the hypnotic effects of its other constituents.https://www.mdpi.com/2072-6643/15/4/1042arousal-inducing effectcaffeine<i>Camellia sinensis</i> L.green tea ethanol extractpolysomnographic recording |
| spellingShingle | Duhyeon Kim Seonghui Kim Minseok Yoon Min Young Um Suengmok Cho Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine Nutrients arousal-inducing effect caffeine <i>Camellia sinensis</i> L. green tea ethanol extract polysomnographic recording |
| title | Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine |
| title_full | Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine |
| title_fullStr | Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine |
| title_full_unstemmed | Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine |
| title_short | Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine |
| title_sort | effects of chronic administration of green tea ethanol extract on sleep architecture in mice a comparative study with a representative stimulant caffeine |
| topic | arousal-inducing effect caffeine <i>Camellia sinensis</i> L. green tea ethanol extract polysomnographic recording |
| url | https://www.mdpi.com/2072-6643/15/4/1042 |
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