Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study
Huijun Chen,1,* Yuntao Liu,1,* Guiqian Huang,1,* Jie Zhu,2 Wenqian Feng,2 Jincai He1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; 2Department of Mental Health, Mental Health School, Wenzhou Medical University, Wenzhou 325000, China *...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-12-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-between-vitamin-d-status-and-cognitive-impairment-in-acute-peer-reviewed-article-CIA |
| _version_ | 1819202850168766464 |
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| author | Chen H Liu Y Huang G Zhu J Feng W He J |
| author_facet | Chen H Liu Y Huang G Zhu J Feng W He J |
| author_sort | Chen H |
| collection | DOAJ |
| description | Huijun Chen,1,* Yuntao Liu,1,* Guiqian Huang,1,* Jie Zhu,2 Wenqian Feng,2 Jincai He1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; 2Department of Mental Health, Mental Health School, Wenzhou Medical University, Wenzhou 325000, China *These authors contributed equally to this work Objective: Previous studies found that low vitamin D levels were modestly associated with risk of stroke and poor functional outcome after stroke. In addition, vitamin D deficiency has been linked with cognitive decline. Our study aimed to explore the potential relationship between vitamin D levels in the short-term acute phase of ischemic stroke and cognitive impairment at 1 month. Methods: In total, 354 ischemic stroke patients were consecutively enrolled in the study and received 1-month follow-up. The serum levels of vitamin D were measured within 24 hours after admission. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE) at 1 month after acute ischemic stroke. Cognitive impairment was defined according to different education levels. Results: According to MMSE scores, 114 participants (32.2%) had cognitive impairment at 1 month. Patients with vitamin D deficiency were more likely to have cognitive impairment than those with vitamin D insufficiency and vitamin D sufficiency (P<0.001). After adjusting for potential confounders in our Cox proportional hazards model, vitamin D deficiency was independently associated with the development of cognitive impairment in acute ischemic stroke patients. Conclusion: Independent of established risk factors, vitamin D deficiency in the short-term phase of ischemic stroke was associated with a higher incidence of 1-month cognitive impairment. Keywords: vitamin D, cognitive impairment, ischemic stroke, Mini-Mental State Examination |
| first_indexed | 2024-12-23T04:10:34Z |
| format | Article |
| id | doaj.art-5bd988dbfc3743dfb295caf6872a14de |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-23T04:10:34Z |
| publishDate | 2018-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-5bd988dbfc3743dfb295caf6872a14de2022-12-21T18:00:31ZengDove Medical PressClinical Interventions in Aging1178-19982018-12-01Volume 132503250942933Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort studyChen HLiu YHuang GZhu JFeng WHe JHuijun Chen,1,* Yuntao Liu,1,* Guiqian Huang,1,* Jie Zhu,2 Wenqian Feng,2 Jincai He1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; 2Department of Mental Health, Mental Health School, Wenzhou Medical University, Wenzhou 325000, China *These authors contributed equally to this work Objective: Previous studies found that low vitamin D levels were modestly associated with risk of stroke and poor functional outcome after stroke. In addition, vitamin D deficiency has been linked with cognitive decline. Our study aimed to explore the potential relationship between vitamin D levels in the short-term acute phase of ischemic stroke and cognitive impairment at 1 month. Methods: In total, 354 ischemic stroke patients were consecutively enrolled in the study and received 1-month follow-up. The serum levels of vitamin D were measured within 24 hours after admission. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE) at 1 month after acute ischemic stroke. Cognitive impairment was defined according to different education levels. Results: According to MMSE scores, 114 participants (32.2%) had cognitive impairment at 1 month. Patients with vitamin D deficiency were more likely to have cognitive impairment than those with vitamin D insufficiency and vitamin D sufficiency (P<0.001). After adjusting for potential confounders in our Cox proportional hazards model, vitamin D deficiency was independently associated with the development of cognitive impairment in acute ischemic stroke patients. Conclusion: Independent of established risk factors, vitamin D deficiency in the short-term phase of ischemic stroke was associated with a higher incidence of 1-month cognitive impairment. Keywords: vitamin D, cognitive impairment, ischemic stroke, Mini-Mental State Examinationhttps://www.dovepress.com/association-between-vitamin-d-status-and-cognitive-impairment-in-acute-peer-reviewed-article-CIAvitamin Dcognitive impairmentischemic strokethe Mini-Mental State Examination |
| spellingShingle | Chen H Liu Y Huang G Zhu J Feng W He J Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study Clinical Interventions in Aging vitamin D cognitive impairment ischemic stroke the Mini-Mental State Examination |
| title | Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study |
| title_full | Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study |
| title_fullStr | Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study |
| title_full_unstemmed | Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study |
| title_short | Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study |
| title_sort | association between vitamin d status and cognitive impairment in acute ischemic stroke patients a prospective cohort study |
| topic | vitamin D cognitive impairment ischemic stroke the Mini-Mental State Examination |
| url | https://www.dovepress.com/association-between-vitamin-d-status-and-cognitive-impairment-in-acute-peer-reviewed-article-CIA |
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