The use of metformin as an add-on therapy to insulin in the treatment of poorly controlled type 1 diabetes mellitus in adolescents
The aim of this integrative literature review was to evaluate the efficacy and safety of Metformin as an add-on therapy to insulin in poorly controlled overweight adolescents with type 1 diabetes mellitus. The research problem centered on providing optimum disease management during the most critical...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Metabolism Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589936821000049 |
| _version_ | 1819161104729767936 |
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| author | Katsiaryna Sikorskaya, BSN, RN, CSN Iwona Zarzecka, BSN, RN Uzoamaka Ejikeme, BSN, RN Jennifer Russell, BSN, RN |
| author_facet | Katsiaryna Sikorskaya, BSN, RN, CSN Iwona Zarzecka, BSN, RN Uzoamaka Ejikeme, BSN, RN Jennifer Russell, BSN, RN |
| author_sort | Katsiaryna Sikorskaya, BSN, RN, CSN |
| collection | DOAJ |
| description | The aim of this integrative literature review was to evaluate the efficacy and safety of Metformin as an add-on therapy to insulin in poorly controlled overweight adolescents with type 1 diabetes mellitus. The research problem centered on providing optimum disease management during the most critical growth period and reducing the potential for cardiovascular-related morbidity and mortality in the future. The findings suggested that Metformin, in conjunction with insulin therapy, helped patients to achieve better metabolic control. The quality of metabolic control varied between studies according to differences in study design, exclusion and inclusion criteria, and methods. Adjunctive Metformin therapy has a positive effect on diabetes management, treatment, and prevention of cardiovascular-related complications with a minimal risk of side effects. Suggestions for further exploration of the research results and clinical implications are included in the review. |
| first_indexed | 2024-12-22T17:07:02Z |
| format | Article |
| id | doaj.art-5bdb6732e8144612819d1435a402233c |
| institution | Directory Open Access Journal |
| issn | 2589-9368 |
| language | English |
| last_indexed | 2024-12-22T17:07:02Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj.art-5bdb6732e8144612819d1435a402233c2022-12-21T18:19:11ZengElsevierMetabolism Open2589-93682021-03-019100080The use of metformin as an add-on therapy to insulin in the treatment of poorly controlled type 1 diabetes mellitus in adolescentsKatsiaryna Sikorskaya, BSN, RN, CSN0Iwona Zarzecka, BSN, RN1Uzoamaka Ejikeme, BSN, RN2Jennifer Russell, BSN, RN3Corresponding author.; Rutgers University School of Nursing, USARutgers University School of Nursing, USARutgers University School of Nursing, USARutgers University School of Nursing, USAThe aim of this integrative literature review was to evaluate the efficacy and safety of Metformin as an add-on therapy to insulin in poorly controlled overweight adolescents with type 1 diabetes mellitus. The research problem centered on providing optimum disease management during the most critical growth period and reducing the potential for cardiovascular-related morbidity and mortality in the future. The findings suggested that Metformin, in conjunction with insulin therapy, helped patients to achieve better metabolic control. The quality of metabolic control varied between studies according to differences in study design, exclusion and inclusion criteria, and methods. Adjunctive Metformin therapy has a positive effect on diabetes management, treatment, and prevention of cardiovascular-related complications with a minimal risk of side effects. Suggestions for further exploration of the research results and clinical implications are included in the review.http://www.sciencedirect.com/science/article/pii/S2589936821000049Children with type 1 diabetes and metforminAdjunctive therapy to insulin in adolescents with type 1 diabetesMetformin and type 1 diabetes |
| spellingShingle | Katsiaryna Sikorskaya, BSN, RN, CSN Iwona Zarzecka, BSN, RN Uzoamaka Ejikeme, BSN, RN Jennifer Russell, BSN, RN The use of metformin as an add-on therapy to insulin in the treatment of poorly controlled type 1 diabetes mellitus in adolescents Metabolism Open Children with type 1 diabetes and metformin Adjunctive therapy to insulin in adolescents with type 1 diabetes Metformin and type 1 diabetes |
| title | The use of metformin as an add-on therapy to insulin in the treatment of poorly controlled type 1 diabetes mellitus in adolescents |
| title_full | The use of metformin as an add-on therapy to insulin in the treatment of poorly controlled type 1 diabetes mellitus in adolescents |
| title_fullStr | The use of metformin as an add-on therapy to insulin in the treatment of poorly controlled type 1 diabetes mellitus in adolescents |
| title_full_unstemmed | The use of metformin as an add-on therapy to insulin in the treatment of poorly controlled type 1 diabetes mellitus in adolescents |
| title_short | The use of metformin as an add-on therapy to insulin in the treatment of poorly controlled type 1 diabetes mellitus in adolescents |
| title_sort | use of metformin as an add on therapy to insulin in the treatment of poorly controlled type 1 diabetes mellitus in adolescents |
| topic | Children with type 1 diabetes and metformin Adjunctive therapy to insulin in adolescents with type 1 diabetes Metformin and type 1 diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S2589936821000049 |
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