Novel Antimicrobial Peptide Dendrimers with Amphiphilic Surface and Their Interactions with Phospholipids — Insights from Mass Spectrometry

Novel Antimicrobial Peptide Dendrimers with Amphiphilic Surface and Their Interactions with Phospholipids — Insights from Mass Spectrometry

A series of new peptide dendrimers with amphiphilic surface, designed around a dendronized ornithine (Orn) core were synthesized and characterized by ESI-MS, 1H-, 13C- NMR, and CD spectrometry. An improved antimicrobial potency against S. aureus and E. coli was detected as a result of an increased c...

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Bibliographic Details
Main Authors: Paulina Zielinska, Magdalena Zimnicka, Anna Troć, Przemysław Kalicki, Jolanta Solecka, Anna Laskowska, Zofia Urbanczyk-Lipkowska, Piotr Polcyn
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Molecules
Subjects:
dendrimers
peptides
amphiphilic surface
antimicrobial
high salt conditions
circular dichroism
phospholipids
ESI-MS
collision-induced dissociation (CID)
Online Access:http://www.mdpi.com/1420-3049/18/6/7120

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