New Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Inhibitors, Nalidixic Acid Linked to Isatin Schiff Bases via Certain l-Amino Acid Bridges

New Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Inhibitors, Nalidixic Acid Linked to Isatin Schiff Bases via Certain l-Amino Acid Bridges

A series of new Schiff bases were synthesized by condensation of isatins with the nalidixic acid-l-amino acid hydrazides. Prior to hydrazide formation, a peptide linkage has been prepared via coupling of nalidixic acid with appropriate l-amino acid methyl esters to yield 3a–c. The chemical structure...

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Bibliographic Details
Main Authors:	Ahmed M. Naglah, Atallah F. Ahmed, Zhi-Hong Wen, Mohamed A. Al-Omar, Abd El-Galil E. Amr, Atef Kalmouch
Format:	Article
Language:	English
Published:	MDPI AG 2016-04-01
Series:	Molecules
Subjects:	nalidixic acid isatin ">l-amino acid Schiff base iNOS COX-2 anti-inflammatory microwave irradiation
Online Access:	http://www.mdpi.com/1420-3049/21/4/498

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