Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma
Abstract Background Ferroptosis is a recently recognised new type of cell death which may be a potential target for cancer therapy. In the present study, we aimed to screen ferroptosis-related differentially expressed long non-coding RNAs as biomarkers to predict the outcome of kidney renal clear ce...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-021-02284-1 |
| _version_ | 1818429729268563968 |
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| author | Xiao-Liang Xing Zhi-Yong Yao Jialan Ou Chaoqun Xing Feng Li |
| author_facet | Xiao-Liang Xing Zhi-Yong Yao Jialan Ou Chaoqun Xing Feng Li |
| author_sort | Xiao-Liang Xing |
| collection | DOAJ |
| description | Abstract Background Ferroptosis is a recently recognised new type of cell death which may be a potential target for cancer therapy. In the present study, we aimed to screen ferroptosis-related differentially expressed long non-coding RNAs as biomarkers to predict the outcome of kidney renal clear cell carcinoma. Methods RNAseq count data and corresponding clinical information were obtained from the Cancer Genome Atlas database. Lists of ferroptosis-related genes and long non-coding RNAs were obtained from the FerrDb and GENCODE databases, respectively. The candidate prognostic signatures were screened by Cox regression analyses and least absolute shrinkage and selection operator analyses. Results Three ferroptosis-related long non-coding RNAs (DUXAP8, LINC02609, and LUCAT1) were significantly correlated with the overall survival of kidney renal clear cell carcinoma independently. Kidney renal clear cell carcinoma patients with high-risk values displayed worse OS. Meanwhile, the expression of these three ferroptosis-related long non-coding RNAs and their risk scores were significantly correlated with clinicopathological features. Principal component analyses showed that patients with kidney renal clear cell carcinoma have differential risk values were well distinguished by the three ferroptosis-related long non-coding RNAs. Conclusions The present study suggests that the risk assessment model constructed by these three ferroptosis-related long non-coding RNAs could accurately predict the outcome of kidney renal clear cell carcinoma. We also provide a novel perspective for cancer prognosis screening. |
| first_indexed | 2024-12-14T15:22:08Z |
| format | Article |
| id | doaj.art-5bde10f48a5b4a76ab2a50d84942b639 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-14T15:22:08Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-5bde10f48a5b4a76ab2a50d84942b6392022-12-21T22:56:07ZengBMCCancer Cell International1475-28672021-11-0121111110.1186/s12935-021-02284-1Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinomaXiao-Liang Xing0Zhi-Yong Yao1Jialan Ou2Chaoqun Xing3Feng Li4The First Affiliated Hospital, Hunan University of MedicineSchool of Public Health and Laboratory Medicine, Hunan University of MedicineThe First Affiliated Hospital, Hunan University of MedicineThe First Affiliated Hospital, Hunan University of MedicineThe First Affiliated Hospital, Hunan University of MedicineAbstract Background Ferroptosis is a recently recognised new type of cell death which may be a potential target for cancer therapy. In the present study, we aimed to screen ferroptosis-related differentially expressed long non-coding RNAs as biomarkers to predict the outcome of kidney renal clear cell carcinoma. Methods RNAseq count data and corresponding clinical information were obtained from the Cancer Genome Atlas database. Lists of ferroptosis-related genes and long non-coding RNAs were obtained from the FerrDb and GENCODE databases, respectively. The candidate prognostic signatures were screened by Cox regression analyses and least absolute shrinkage and selection operator analyses. Results Three ferroptosis-related long non-coding RNAs (DUXAP8, LINC02609, and LUCAT1) were significantly correlated with the overall survival of kidney renal clear cell carcinoma independently. Kidney renal clear cell carcinoma patients with high-risk values displayed worse OS. Meanwhile, the expression of these three ferroptosis-related long non-coding RNAs and their risk scores were significantly correlated with clinicopathological features. Principal component analyses showed that patients with kidney renal clear cell carcinoma have differential risk values were well distinguished by the three ferroptosis-related long non-coding RNAs. Conclusions The present study suggests that the risk assessment model constructed by these three ferroptosis-related long non-coding RNAs could accurately predict the outcome of kidney renal clear cell carcinoma. We also provide a novel perspective for cancer prognosis screening.https://doi.org/10.1186/s12935-021-02284-1KIRCFerroptosislncRNAPrognosis signatures |
| spellingShingle | Xiao-Liang Xing Zhi-Yong Yao Jialan Ou Chaoqun Xing Feng Li Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma Cancer Cell International KIRC Ferroptosis lncRNA Prognosis signatures |
| title | Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma |
| title_full | Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma |
| title_fullStr | Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma |
| title_full_unstemmed | Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma |
| title_short | Development and validation of ferroptosis-related lncRNAs prognosis signatures in kidney renal clear cell carcinoma |
| title_sort | development and validation of ferroptosis related lncrnas prognosis signatures in kidney renal clear cell carcinoma |
| topic | KIRC Ferroptosis lncRNA Prognosis signatures |
| url | https://doi.org/10.1186/s12935-021-02284-1 |
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