Autophagy Impairment in App Knock-in Alzheimer’s Model Mice

Autophagy Impairment in App Knock-in Alzheimer’s Model Mice

Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its effect on protein homeostasis including autophagy. Here we comp...

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Bibliographic Details
Main Authors: Richeng Jiang, Makoto Shimozawa, Johanna Mayer, Simone Tambaro, Rakesh Kumar, Axel Abelein, Bengt Winblad, Nenad Bogdanovic, Per Nilsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
APP knock-in mice
autophagy
amyloid beta
protein homeostasis
p62
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.878303/full

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