Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson’s Disease
BackgroundDeep brain stimulation (DBS) improves motor and non-motor symptoms in patients with Parkinson’s disease (PD). Researchers mainly investigated the motor networks to reveal DBS mechanisms, with few studies extending to other networks. This study aimed to investigate multi-network modulation...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.794987/full |
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| author | Yutong Bai Yu Diao Lu Gan Zhizheng Zhuo Zixiao Yin Tianqi Hu Dan Cheng Hutao Xie Delong Wu Houyou Fan Quan Zhang Yunyun Duan Fangang Meng Yaou Liu Yin Jiang Jianguo Zhang Jianguo Zhang Jianguo Zhang |
| author_facet | Yutong Bai Yu Diao Lu Gan Zhizheng Zhuo Zixiao Yin Tianqi Hu Dan Cheng Hutao Xie Delong Wu Houyou Fan Quan Zhang Yunyun Duan Fangang Meng Yaou Liu Yin Jiang Jianguo Zhang Jianguo Zhang Jianguo Zhang |
| author_sort | Yutong Bai |
| collection | DOAJ |
| description | BackgroundDeep brain stimulation (DBS) improves motor and non-motor symptoms in patients with Parkinson’s disease (PD). Researchers mainly investigated the motor networks to reveal DBS mechanisms, with few studies extending to other networks. This study aimed to investigate multi-network modulation patterns using DBS in patients with PD.MethodsTwenty-four patients with PD underwent 1.5 T functional MRI (fMRI) scans in both DBS-on and DBS-off states, with twenty-seven age-matched healthy controls (HCs). Default mode, sensorimotor, salience, and left and right frontoparietal networks were identified by using the independent component analysis. Power spectra and functional connectivity of these networks were calculated. In addition, multiregional connectivity was established from 15 selected regions extracted from the abovementioned networks. Comparisons were made among groups. Finally, correlation analyses were performed between the connectivity changes and symptom improvements.ResultsCompared with HCs, PD-off showed abnormal power spectra and functional connectivity both within and among these networks. Some of the abovementioned abnormalities could be corrected by DBS, including increasing the power spectra in the sensorimotor network and modulating the parts of the ipsilateral functional connectivity in different regions centered in the frontoparietal network. Moreover, the DBS-induced functional connectivity changes were correlated with motor and depression improvements in patients with PD.ConclusionDBS modulated the abnormalities in multi-networks. The functional connectivity alterations were associated with motor and psychiatric improvements in PD. This study lays the foundation for large-scale brain network research on multi-network DBS modulation. |
| first_indexed | 2024-12-18T10:55:40Z |
| format | Article |
| id | doaj.art-5bdf0fe2923d43008d52f134aac632b9 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-18T10:55:40Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-5bdf0fe2923d43008d52f134aac632b92022-12-21T21:10:21ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-03-011410.3389/fnagi.2022.794987794987Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson’s DiseaseYutong Bai0Yu Diao1Lu Gan2Zhizheng Zhuo3Zixiao Yin4Tianqi Hu5Dan Cheng6Hutao Xie7Delong Wu8Houyou Fan9Quan Zhang10Yunyun Duan11Fangang Meng12Yaou Liu13Yin Jiang14Jianguo Zhang15Jianguo Zhang16Jianguo Zhang17Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Neurosurgical Institute, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Neurosurgical Institute, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaBackgroundDeep brain stimulation (DBS) improves motor and non-motor symptoms in patients with Parkinson’s disease (PD). Researchers mainly investigated the motor networks to reveal DBS mechanisms, with few studies extending to other networks. This study aimed to investigate multi-network modulation patterns using DBS in patients with PD.MethodsTwenty-four patients with PD underwent 1.5 T functional MRI (fMRI) scans in both DBS-on and DBS-off states, with twenty-seven age-matched healthy controls (HCs). Default mode, sensorimotor, salience, and left and right frontoparietal networks were identified by using the independent component analysis. Power spectra and functional connectivity of these networks were calculated. In addition, multiregional connectivity was established from 15 selected regions extracted from the abovementioned networks. Comparisons were made among groups. Finally, correlation analyses were performed between the connectivity changes and symptom improvements.ResultsCompared with HCs, PD-off showed abnormal power spectra and functional connectivity both within and among these networks. Some of the abovementioned abnormalities could be corrected by DBS, including increasing the power spectra in the sensorimotor network and modulating the parts of the ipsilateral functional connectivity in different regions centered in the frontoparietal network. Moreover, the DBS-induced functional connectivity changes were correlated with motor and depression improvements in patients with PD.ConclusionDBS modulated the abnormalities in multi-networks. The functional connectivity alterations were associated with motor and psychiatric improvements in PD. This study lays the foundation for large-scale brain network research on multi-network DBS modulation.https://www.frontiersin.org/articles/10.3389/fnagi.2022.794987/fullParkinson’s diseasedeep brain stimulationresting-state networkfunctional connectivitypower spectrafrontoparietal network |
| spellingShingle | Yutong Bai Yu Diao Lu Gan Zhizheng Zhuo Zixiao Yin Tianqi Hu Dan Cheng Hutao Xie Delong Wu Houyou Fan Quan Zhang Yunyun Duan Fangang Meng Yaou Liu Yin Jiang Jianguo Zhang Jianguo Zhang Jianguo Zhang Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson’s Disease Frontiers in Aging Neuroscience Parkinson’s disease deep brain stimulation resting-state network functional connectivity power spectra frontoparietal network |
| title | Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson’s Disease |
| title_full | Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson’s Disease |
| title_fullStr | Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson’s Disease |
| title_full_unstemmed | Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson’s Disease |
| title_short | Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson’s Disease |
| title_sort | deep brain stimulation modulates multiple abnormal resting state network connectivity in patients with parkinson s disease |
| topic | Parkinson’s disease deep brain stimulation resting-state network functional connectivity power spectra frontoparietal network |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.794987/full |
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