Allergen-Specific Immunotherapy in Patients 55 Years and Older: Results and Review of Literature
Abstract Introduction Over the years the immune system suffers many morphologic and functional alterations, which result in a peak of function in puberty and a gradual decrease in the elderly. Aim Treat patients 55 years or older with allergic rhinitis with immunotherapy an...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2013-09-01
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| Series: | International Archives of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1353138 |
| _version_ | 1818339801326157824 |
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| author | Eduardo Baptistella Sergio Maniglia Diego Augusto Malucelli Daniel Rispoli Thanara Pruner de Silva Fernanda Miyoko Tsuru Renata Vecentin Becker Gustavo Bernardi Daniela Dranka Bruno Ferraz |
| author_facet | Eduardo Baptistella Sergio Maniglia Diego Augusto Malucelli Daniel Rispoli Thanara Pruner de Silva Fernanda Miyoko Tsuru Renata Vecentin Becker Gustavo Bernardi Daniela Dranka Bruno Ferraz |
| author_sort | Eduardo Baptistella |
| collection | DOAJ |
| description | Abstract
Introduction Over the years the immune system suffers many morphologic and functional alterations, which result in a peak of function in puberty and a gradual decrease in the elderly.
Aim Treat patients 55 years or older with allergic rhinitis with immunotherapy and then analyze the response to allergens.
Materials and Methods From June 2009 to July 2010, 104 charts of patients 55 years or older with allergic complaints were evaluated. The patients were selected by anamnesis, physical examination, and otorhinolaryngologic exam. The patients had cutaneous test for mites before and after 1 year of sublingual specific immunotherapy. The cutaneous response was classified as negative (absent), light, moderate, or severe.
Results Before vaccination, 42 (40.4%) patients were classified as having a severe form of allergy and 62 (59.6%) as having a moderate allergy. After the specific therapy, 40 (38.4%) patients were classified as negative (absent), 37 (35.6%) as light, 19 (18.3%) as moderate, and 8 (7.7%) as severe responses.
Conclusion Immunotherapy, a desensitization technique, is indicated in cases which patients cannot avoid the exposure to allergens and in situations where pharmacologic therapy is not ideal. Specific immunotherapy to treat the allergic rhinitis in elderly patients was efficient and had no collateral effects, and in addition to the clinical benefit, improvement in the cutaneous test could also be observed. |
| first_indexed | 2024-12-13T15:32:47Z |
| format | Article |
| id | doaj.art-5be1cf2a0c4c4a42a582092ad253d61d |
| institution | Directory Open Access Journal |
| issn | 1809-9777 1809-4864 |
| language | English |
| last_indexed | 2024-12-13T15:32:47Z |
| publishDate | 2013-09-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | International Archives of Otorhinolaryngology |
| spelling | doaj.art-5be1cf2a0c4c4a42a582092ad253d61d2022-12-21T23:40:08ZengThieme Revinter Publicações Ltda.International Archives of Otorhinolaryngology1809-97771809-48642013-09-01170437537910.1055/s-0033-1353138Allergen-Specific Immunotherapy in Patients 55 Years and Older: Results and Review of LiteratureEduardo Baptistella0Sergio Maniglia1Diego Augusto Malucelli2Daniel Rispoli3Thanara Pruner de Silva4Fernanda Miyoko Tsuru5Renata Vecentin Becker6Gustavo Bernardi7Daniela Dranka8Bruno Ferraz9Centro Médico Especializado Baptistella (CMEB), Curitiba/PR, BrazilCentro Médico Especializado Baptistella (CMEB), Curitiba/PR, BrazilCentro Médico Especializado Baptistella (CMEB), Curitiba/PR, BrazilCentro Médico Especializado Baptistella (CMEB), Curitiba/PR, BrazilCentro Médico Especializado Baptistella (CMEB), Curitiba/PR, BrazilCentro Médico Especializado Baptistella (CMEB), Curitiba/PR, BrazilCentro Médico Especializado Baptistella (CMEB), Curitiba/PR, BrazilCentro Médico Especializado Baptistella (CMEB), Curitiba/PR, BrazilCentro Médico Especializado Baptistella (CMEB), Curitiba/PR, BrazilCentro Médico Especializado Baptistella (CMEB), Curitiba/PR, BrazilAbstract Introduction Over the years the immune system suffers many morphologic and functional alterations, which result in a peak of function in puberty and a gradual decrease in the elderly. Aim Treat patients 55 years or older with allergic rhinitis with immunotherapy and then analyze the response to allergens. Materials and Methods From June 2009 to July 2010, 104 charts of patients 55 years or older with allergic complaints were evaluated. The patients were selected by anamnesis, physical examination, and otorhinolaryngologic exam. The patients had cutaneous test for mites before and after 1 year of sublingual specific immunotherapy. The cutaneous response was classified as negative (absent), light, moderate, or severe. Results Before vaccination, 42 (40.4%) patients were classified as having a severe form of allergy and 62 (59.6%) as having a moderate allergy. After the specific therapy, 40 (38.4%) patients were classified as negative (absent), 37 (35.6%) as light, 19 (18.3%) as moderate, and 8 (7.7%) as severe responses. Conclusion Immunotherapy, a desensitization technique, is indicated in cases which patients cannot avoid the exposure to allergens and in situations where pharmacologic therapy is not ideal. Specific immunotherapy to treat the allergic rhinitis in elderly patients was efficient and had no collateral effects, and in addition to the clinical benefit, improvement in the cutaneous test could also be observed.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1353138immunotherapyagedrhinitis |
| spellingShingle | Eduardo Baptistella Sergio Maniglia Diego Augusto Malucelli Daniel Rispoli Thanara Pruner de Silva Fernanda Miyoko Tsuru Renata Vecentin Becker Gustavo Bernardi Daniela Dranka Bruno Ferraz Allergen-Specific Immunotherapy in Patients 55 Years and Older: Results and Review of Literature International Archives of Otorhinolaryngology immunotherapy aged rhinitis |
| title | Allergen-Specific Immunotherapy in Patients 55 Years and Older: Results and Review of Literature |
| title_full | Allergen-Specific Immunotherapy in Patients 55 Years and Older: Results and Review of Literature |
| title_fullStr | Allergen-Specific Immunotherapy in Patients 55 Years and Older: Results and Review of Literature |
| title_full_unstemmed | Allergen-Specific Immunotherapy in Patients 55 Years and Older: Results and Review of Literature |
| title_short | Allergen-Specific Immunotherapy in Patients 55 Years and Older: Results and Review of Literature |
| title_sort | allergen specific immunotherapy in patients 55 years and older results and review of literature |
| topic | immunotherapy aged rhinitis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1353138 |
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