Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease.

Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease.

The ability to reconstitute a normal immune system with antiretroviral therapy in the setting of HIV infection remains uncertain. This study aimed to characterize quantitative and qualitative aspects of various T cell subpopulations that do not improve despite effective ART. CD4∶CD8 ratio was evalua...

Full description

Bibliographic Details
Main Authors:	Brinda Emu, Walter J Moretto, Rebecca Hoh, Melissa Krone, Jeffrey N Martin, Douglas F Nixon, Steven G Deeks, Joseph M McCune
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3897457?pdf=render

Similar Items

IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells
by: Martin Jeffrey N, et al.
Published: (2006-07-01)

The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
by: Natalie F. McMyn, et al.
Published: (2023-09-01)

Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease.
by: David M Naeger, et al.
Published: (2010-01-01)

Potential inflammatory consequences in HIV controllers
by: Martin Jeffrey N, et al.
Published: (2010-05-01)

A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers.
by: Peter W Hunt, et al.
Published: (2011-01-01)

Cerebrospinal fluid soluble CD30 elevation despite suppressive antiretroviral therapy in individuals living with HIV-1
by: Michael J. Peluso, et al.
Published: (2020-01-01)

CD4+CD25high Regulatory T Cells in the Developing Human Immune System: Implications for Pediatric HIV Infection
by: McCune Joseph M, et al.
Published: (2005-12-01)

Higher CD27+CD8+ T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4+ T cell recovery in treated HIV infection.
by: Lillian Seu, et al.
Published: (2013-01-01)

Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy
by: Yuyang Tang, et al.
Published: (2023-06-01)

Disseminated rhodococcus equi infection in HIV infection despite highly active antiretroviral therapy
by: Ferretti Francesca, et al.
Published: (2011-12-01)

Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy
by: Genevieve E. Martin, et al.
Published: (2021-06-01)

Direct measurement of CD4+ and CD8+ T-cell responses to CMV in HIV-1-infected subjects.
by: Komanduri, K, et al.
Published: (2001)

The Benefits of Early Antiretroviral Therapy for HIV Infection: How Early is Early Enough?
by: Sulggi A. Lee, et al.
Published: (2016-09-01)

P08-01. Heme oxygenase-1 promoter polymorphisms correlate with favorable virologic and immunological parameters in HIV-1 infection
by: McCune JM, et al.
Published: (2009-10-01)

Diminished physical function in older HIV-infected adults in the Southeastern U.S. despite successful antiretroviral therapy.
by: Audrey L Khoury, et al.
Published: (2017-01-01)

KIR-HLA genotypes in HIV-infected patients lacking immunological recovery despite effective antiretroviral therapy.
by: Alessandro Soria, et al.
Published: (2011-01-01)

Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy.
by: Sulggi A Lee, et al.
Published: (2016-01-01)

HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.
by: Timothy J Henrich, et al.
Published: (2017-11-01)

Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence
by: Daniel B. Reeves, et al.
Published: (2023-10-01)

A slow-cycling/quiescent cells subpopulation is involved in glioma invasiveness
by: Francesco Antonica, et al.
Published: (2022-08-01)

The promise of a “cure” for HIV: implications for the future of PEPFAR‐supported HIV programmes
by: Elliot Raizes, et al.
Published: (2024-01-01)

Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication.
by: Le, T, et al.
Published: (2011)

Rapid CD4 decline prior to antiretroviral therapy predicts subsequent failure to reconstitute despite HIV viral suppression
by: Majid Darraj, et al.
Published: (2018-03-01)

Persistence of Activated and Adaptive-Like NK Cells in HIV+ Individuals despite 2 Years of Suppressive Combination Antiretroviral Therapy
by: Anna C. Hearps, et al.
Published: (2017-06-01)

Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy
by: Singh, Alveera, et al.
Published: (2022)

Low rates of repeat HIV testing despite increased availability of antiretroviral therapy in rural Tanzania: findings from 2003-2010.
by: Caoimhe Cawley, et al.
Published: (2013-01-01)

The risk of virologic failure decreases with duration of HIV suppression, at greater than 50% adherence to antiretroviral therapy.
by: Michael Rosenblum, et al.
Published: (2009-09-01)

Intact HIV genomes are enriched in memory T cells with short half-lives
by: V. Morcilla, et al.
Published: (2019-12-01)

Learner identities and the will to understand: The experiences of undergraduate biosciences students in the UK
by: Velda McCune
Published: (2020-10-01)

Posthumanism and Higher Education: Reimagining Pedagogy, Practice and Research
by: Velda McCune
Published: (2019-12-01)

Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy
by: Eunok Lee, et al.
Published: (2019-09-01)

A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals
by: Leslie Renee Cockerham, et al.
Published: (2017-08-01)

Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV
by: Zhenwu Luo, et al.
Published: (2022-06-01)

Virologic suppression in response to antiretroviral therapy despite extensive resistance within HIV-1 reverse transcriptase after the first virologic failure
by: Marta Iglis Oliveira, et al.
Published: (2018-10-01)

HIV-1 Genomes Are Enriched in Memory CD4 <sup>+</sup> T-Cells with Short Half-Lives
by: Vincent Morcilla, et al.
Published: (2021-10-01)

TCF-1 expression is associated with HIV-specific CD8+ T cell proliferative capacity
by: R. Rutishauser, et al.
Published: (2017-12-01)

Cerebrospinal fluid HIV infection and pleocytosis: Relation to systemic infection and antiretroviral treatment
by: Petropoulos Christos J, et al.
Published: (2005-11-01)

Intraepithelial γδ T cells remain increased in the duodenum of AIDS patients despite antiretroviral treatment.
by: Dag E Nilssen, et al.
Published: (2012-01-01)

IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo.
by: Cheryl A Stoddart, et al.
Published: (2010-02-01)

Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways.
by: Mingwei Min, et al.
Published: (2019-03-01)