Association of a bovine prion gene haplotype with atypical BSE.
BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE. METHODOLOGY/PRINCIPLE FINDINGS:...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2263129?pdf=render |
| _version_ | 1818262946973745152 |
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| author | Michael L Clawson Juergen A Richt Thierry Baron Anne-Gaëlle Biacabe Stefanie Czub Michael P Heaton Timothy P L Smith William W Laegreid |
| author_facet | Michael L Clawson Juergen A Richt Thierry Baron Anne-Gaëlle Biacabe Stefanie Czub Michael P Heaton Timothy P L Smith William W Laegreid |
| author_sort | Michael L Clawson |
| collection | DOAJ |
| description | BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE. METHODOLOGY/PRINCIPLE FINDINGS: Haplotype tagging polymorphisms that characterize PRNP haplotypes from the promoter region through the three prime untranslated region of exon 3 (25.2 kb) were used to determine PRNP haplotypes of six available atypical BSE cases from Canada, France and the United States. One or two copies of a distinct PRNP haplotype were identified in five of the six cases (p = 1.3 x 10(-4), two-tailed Fisher's exact test; CI(95%) 0.263-0.901, difference between proportions). The haplotype spans a portion of PRNP that includes part of intron 2, the entire coding region of exon 3 and part of the three prime untranslated region of exon 3 (13 kb). CONCLUSIONS/SIGNIFICANCE: This result suggests that a genetic determinant in or near PRNP may influence susceptibility of cattle to atypical BSE. |
| first_indexed | 2024-12-12T19:11:12Z |
| format | Article |
| id | doaj.art-5be2be1feda74052a8d8e0db7e5e3848 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T19:11:12Z |
| publishDate | 2008-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5be2be1feda74052a8d8e0db7e5e38482022-12-22T00:14:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-01-0133e183010.1371/journal.pone.0001830Association of a bovine prion gene haplotype with atypical BSE.Michael L ClawsonJuergen A RichtThierry BaronAnne-Gaëlle BiacabeStefanie CzubMichael P HeatonTimothy P L SmithWilliam W LaegreidBACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE. METHODOLOGY/PRINCIPLE FINDINGS: Haplotype tagging polymorphisms that characterize PRNP haplotypes from the promoter region through the three prime untranslated region of exon 3 (25.2 kb) were used to determine PRNP haplotypes of six available atypical BSE cases from Canada, France and the United States. One or two copies of a distinct PRNP haplotype were identified in five of the six cases (p = 1.3 x 10(-4), two-tailed Fisher's exact test; CI(95%) 0.263-0.901, difference between proportions). The haplotype spans a portion of PRNP that includes part of intron 2, the entire coding region of exon 3 and part of the three prime untranslated region of exon 3 (13 kb). CONCLUSIONS/SIGNIFICANCE: This result suggests that a genetic determinant in or near PRNP may influence susceptibility of cattle to atypical BSE.http://europepmc.org/articles/PMC2263129?pdf=render |
| spellingShingle | Michael L Clawson Juergen A Richt Thierry Baron Anne-Gaëlle Biacabe Stefanie Czub Michael P Heaton Timothy P L Smith William W Laegreid Association of a bovine prion gene haplotype with atypical BSE. PLoS ONE |
| title | Association of a bovine prion gene haplotype with atypical BSE. |
| title_full | Association of a bovine prion gene haplotype with atypical BSE. |
| title_fullStr | Association of a bovine prion gene haplotype with atypical BSE. |
| title_full_unstemmed | Association of a bovine prion gene haplotype with atypical BSE. |
| title_short | Association of a bovine prion gene haplotype with atypical BSE. |
| title_sort | association of a bovine prion gene haplotype with atypical bse |
| url | http://europepmc.org/articles/PMC2263129?pdf=render |
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