The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes

The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes

Fragile X syndrome (FXS) is caused by the loss of function of Fragile X mental retardation protein (FMRP). FXS is one of the leading monogenic causes of intellectual disability (ID) and autism. Although it is caused by the failure of a single gene, FMRP that functions as an RNA binding protein affec...

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Bibliographic Details
Main Authors: Patricia Cogram, Luis C. Fernández-Beltrán, María José Casarejos, Sonia Sánchez-Yepes, Eulalia Rodríguez-Martín, Alfonso García-Rubia, María José Sánchez-Barrena, Carmen Gil, Ana Martínez, Alicia Mansilla
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Neuroscience
Subjects:
Fragile X syndrome
Ncs-1
Ric8a
dopamine
protein-protein interaction inhibitor
Fmr1 knockout
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1007531/full

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