Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes
Osteoarthritis (OA) is a chronic degenerative joint disease that causes pain, physical disability, and life quality impairment. The pathophysiology of OA remains largely unclear, and currently no FDA-approved disease-modifying OA drugs (DMOADs) are available. As has been acknowledged, aging is the p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/11/7/996 |
| _version_ | 1827624655098216448 |
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| author | Yuchen He Katelyn E. Lipa Peter G. Alexander Karen L. Clark Hang Lin |
| author_facet | Yuchen He Katelyn E. Lipa Peter G. Alexander Karen L. Clark Hang Lin |
| author_sort | Yuchen He |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a chronic degenerative joint disease that causes pain, physical disability, and life quality impairment. The pathophysiology of OA remains largely unclear, and currently no FDA-approved disease-modifying OA drugs (DMOADs) are available. As has been acknowledged, aging is the primary independent risk factor for OA, but the mechanisms underlying such a connection are not fully understood. In this review, we first revisit the changes in OA chondrocytes from the perspective of cellular hallmarks of aging. It is concluded that OA chondrocytes share many alterations similar to cellular aging. Next, based on the findings from studies on other cell types and diseases, we propose methods that can potentially reverse osteoarthritic phenotype of chondrocytes back to a healthier state. Lastly, current challenges and future perspectives are summarized. |
| first_indexed | 2024-03-09T12:13:47Z |
| format | Article |
| id | doaj.art-5be7227dec844fdcaa7662eca34c49ee |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T12:13:47Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-5be7227dec844fdcaa7662eca34c49ee2023-11-30T22:49:02ZengMDPI AGBiology2079-77372022-06-0111799610.3390/biology11070996Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of ChondrocytesYuchen He0Katelyn E. Lipa1Peter G. Alexander2Karen L. Clark3Hang Lin4Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15217, USADepartment of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15217, USADepartment of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15217, USADepartment of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15217, USADepartment of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15217, USAOsteoarthritis (OA) is a chronic degenerative joint disease that causes pain, physical disability, and life quality impairment. The pathophysiology of OA remains largely unclear, and currently no FDA-approved disease-modifying OA drugs (DMOADs) are available. As has been acknowledged, aging is the primary independent risk factor for OA, but the mechanisms underlying such a connection are not fully understood. In this review, we first revisit the changes in OA chondrocytes from the perspective of cellular hallmarks of aging. It is concluded that OA chondrocytes share many alterations similar to cellular aging. Next, based on the findings from studies on other cell types and diseases, we propose methods that can potentially reverse osteoarthritic phenotype of chondrocytes back to a healthier state. Lastly, current challenges and future perspectives are summarized.https://www.mdpi.com/2079-7737/11/7/996osteoarthritiscartilage degradationchondrocyteagingsenescence |
| spellingShingle | Yuchen He Katelyn E. Lipa Peter G. Alexander Karen L. Clark Hang Lin Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes Biology osteoarthritis cartilage degradation chondrocyte aging senescence |
| title | Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes |
| title_full | Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes |
| title_fullStr | Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes |
| title_full_unstemmed | Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes |
| title_short | Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes |
| title_sort | potential methods of targeting cellular aging hallmarks to reverse osteoarthritic phenotype of chondrocytes |
| topic | osteoarthritis cartilage degradation chondrocyte aging senescence |
| url | https://www.mdpi.com/2079-7737/11/7/996 |
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