Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes

Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes

Osteoarthritis (OA) is a chronic degenerative joint disease that causes pain, physical disability, and life quality impairment. The pathophysiology of OA remains largely unclear, and currently no FDA-approved disease-modifying OA drugs (DMOADs) are available. As has been acknowledged, aging is the p...

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Bibliographic Details
Main Authors: Yuchen He, Katelyn E. Lipa, Peter G. Alexander, Karen L. Clark, Hang Lin
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biology
Subjects:
osteoarthritis
cartilage degradation
chondrocyte
aging
senescence
Online Access:https://www.mdpi.com/2079-7737/11/7/996

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