Maternal lipid profile during early pregnancy and birth weight: A retrospective study
IntroductionElevated maternal serum lipid concentrations have been related to an adverse intrauterine environment and lead to abnormal birth weight.ObjectiveIn this study, we aimed to explore the association between maternal lipid profiles during early pregnancy and birth weight with stratified pre-...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.951871/full |
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| author | Si-Meng Zhu Si-Meng Zhu Si-Meng Zhu Han-Qiu Zhang Han-Qiu Zhang Han-Qiu Zhang Cheng Li Chen Zhang Chen Zhang Jia-Le Yu Jia-Le Yu Jia-Le Yu Yan-Ting Wu He-Feng Huang He-Feng Huang He-Feng Huang He-Feng Huang |
| author_facet | Si-Meng Zhu Si-Meng Zhu Si-Meng Zhu Han-Qiu Zhang Han-Qiu Zhang Han-Qiu Zhang Cheng Li Chen Zhang Chen Zhang Jia-Le Yu Jia-Le Yu Jia-Le Yu Yan-Ting Wu He-Feng Huang He-Feng Huang He-Feng Huang He-Feng Huang |
| author_sort | Si-Meng Zhu |
| collection | DOAJ |
| description | IntroductionElevated maternal serum lipid concentrations have been related to an adverse intrauterine environment and lead to abnormal birth weight.ObjectiveIn this study, we aimed to explore the association between maternal lipid profiles during early pregnancy and birth weight with stratified pre-pregnancy body mass index (BMI).MethodsThis retrospective cohort study was based on a large population from two major maternity centers in Shanghai, China. We included 57,516 women with singleton live birth between January 2018 and October 2020. All of the enrolled women had fasting lipid concentrations measured in early pregnancy. The primary outcomes were birth weight and risks of adverse birth outcomes, including macrosomia, large for gestational age (LGA), low birth weight (LBW), and small for gestational age (SGA).ResultsHigher maternal concentrations of total cholesterol (TC), triglyceride (TG), and low-density cholesterol (LDL-c) in early pregnancy were associated with increased birth weight. Ln transformed TG and levels exhibited a positive association with LGA and macrosomia (OR = 1.33, 95% CI: 1.25, 1.42 and OR = 1.37, 95% CI: 1.24, 1.52) and showed a negative relationship with SGA (OR = 0.73, 95% CI: 0.62, 0.85). High TG (>75th percentile, 1.67 mmol/L) group also showed higher risks of LGA and macrosomia (OR = 1.21, 95% CI: 1.15, 1.28 and OR = 1.20, 95% CI: 1.10, 1.31) and decreased prevalence of SGA (OR = 0.71, 95% CI: 0.61, 0.83). Moreover, significant combined effects of pre-pregnancy BMI and lipid profiles on LGA and macrosomia were identified.ConclusionsElevated maternal lipid profiles in early pregnancy are associated with higher birth weight and increased risks of LGA and macrosomia. We propose that serum lipid profiles in early pregnancy and pre-pregnancy BMI could serve as screening indexes for high-risk women. |
| first_indexed | 2024-04-11T20:35:08Z |
| format | Article |
| id | doaj.art-5be7810baae5408d8282a0bdbd1bdd25 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T20:35:08Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-5be7810baae5408d8282a0bdbd1bdd252022-12-22T04:04:23ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.951871951871Maternal lipid profile during early pregnancy and birth weight: A retrospective studySi-Meng Zhu0Si-Meng Zhu1Si-Meng Zhu2Han-Qiu Zhang3Han-Qiu Zhang4Han-Qiu Zhang5Cheng Li6Chen Zhang7Chen Zhang8Jia-Le Yu9Jia-Le Yu10Jia-Le Yu11Yan-Ting Wu12He-Feng Huang13He-Feng Huang14He-Feng Huang15He-Feng Huang16International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Disease, Shanghai, ChinaResearch Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, ChinaInternational Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Disease, Shanghai, ChinaResearch Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaInternational Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaInternational Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Disease, Shanghai, ChinaResearch Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaInternational Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Disease, Shanghai, ChinaResearch Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaIntroductionElevated maternal serum lipid concentrations have been related to an adverse intrauterine environment and lead to abnormal birth weight.ObjectiveIn this study, we aimed to explore the association between maternal lipid profiles during early pregnancy and birth weight with stratified pre-pregnancy body mass index (BMI).MethodsThis retrospective cohort study was based on a large population from two major maternity centers in Shanghai, China. We included 57,516 women with singleton live birth between January 2018 and October 2020. All of the enrolled women had fasting lipid concentrations measured in early pregnancy. The primary outcomes were birth weight and risks of adverse birth outcomes, including macrosomia, large for gestational age (LGA), low birth weight (LBW), and small for gestational age (SGA).ResultsHigher maternal concentrations of total cholesterol (TC), triglyceride (TG), and low-density cholesterol (LDL-c) in early pregnancy were associated with increased birth weight. Ln transformed TG and levels exhibited a positive association with LGA and macrosomia (OR = 1.33, 95% CI: 1.25, 1.42 and OR = 1.37, 95% CI: 1.24, 1.52) and showed a negative relationship with SGA (OR = 0.73, 95% CI: 0.62, 0.85). High TG (>75th percentile, 1.67 mmol/L) group also showed higher risks of LGA and macrosomia (OR = 1.21, 95% CI: 1.15, 1.28 and OR = 1.20, 95% CI: 1.10, 1.31) and decreased prevalence of SGA (OR = 0.71, 95% CI: 0.61, 0.83). Moreover, significant combined effects of pre-pregnancy BMI and lipid profiles on LGA and macrosomia were identified.ConclusionsElevated maternal lipid profiles in early pregnancy are associated with higher birth weight and increased risks of LGA and macrosomia. We propose that serum lipid profiles in early pregnancy and pre-pregnancy BMI could serve as screening indexes for high-risk women.https://www.frontiersin.org/articles/10.3389/fendo.2022.951871/fullmaternal lipid profilesbody mass indexbirth weightlarge for gestational agemacrosomia |
| spellingShingle | Si-Meng Zhu Si-Meng Zhu Si-Meng Zhu Han-Qiu Zhang Han-Qiu Zhang Han-Qiu Zhang Cheng Li Chen Zhang Chen Zhang Jia-Le Yu Jia-Le Yu Jia-Le Yu Yan-Ting Wu He-Feng Huang He-Feng Huang He-Feng Huang He-Feng Huang Maternal lipid profile during early pregnancy and birth weight: A retrospective study Frontiers in Endocrinology maternal lipid profiles body mass index birth weight large for gestational age macrosomia |
| title | Maternal lipid profile during early pregnancy and birth weight: A retrospective study |
| title_full | Maternal lipid profile during early pregnancy and birth weight: A retrospective study |
| title_fullStr | Maternal lipid profile during early pregnancy and birth weight: A retrospective study |
| title_full_unstemmed | Maternal lipid profile during early pregnancy and birth weight: A retrospective study |
| title_short | Maternal lipid profile during early pregnancy and birth weight: A retrospective study |
| title_sort | maternal lipid profile during early pregnancy and birth weight a retrospective study |
| topic | maternal lipid profiles body mass index birth weight large for gestational age macrosomia |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.951871/full |
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