Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression
Language regression is observed in a subset of toddlers with autism spectrum disorder (ASD) as initial symptom. However, such a phenomenon has not been fully explored, partly due to the lack of definite diagnostic evaluation methods and criteria. Materials and Methods: Fifteen toddlers with ASD exhi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2018-03-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2018-0014 |
| _version_ | 1818399296855212032 |
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| author | Zhang Lin Li Kailong Zhang Chengqi Qi Xianlong Zheng Ning Wang Guangbin |
| author_facet | Zhang Lin Li Kailong Zhang Chengqi Qi Xianlong Zheng Ning Wang Guangbin |
| author_sort | Zhang Lin |
| collection | DOAJ |
| description | Language regression is observed in a subset of toddlers with autism spectrum disorder (ASD) as initial symptom. However, such a phenomenon has not been fully explored, partly due to the lack of definite diagnostic evaluation methods and criteria. Materials and Methods: Fifteen toddlers with ASD exhibiting language regression and fourteen age-matched typically developing (TD) controls underwent diffusion tensor imaging (DTI). DTI parameters including fractional anisotropy (FA), average fiber length (AFL), tract volume (TV) and number of voxels (NV) were analyzed by Neuro 3D in Siemens syngo workstation. Subsequently, the data were analyzed by using IBM SPSS Statistics 22. Results: Compared with TD children, a significant reduction of FA along with an increase in TV and NV was observed in ASD children with language regression. Note that there were no significant differences between ASD and TD children in AFL of the arcuate fasciculus (AF). Conclusions: These DTI changes in the AF suggest that microstructural anomalies of the AF white matter may be associated with language deficits in ASD children exhibiting language regression starting from an early age. |
| first_indexed | 2024-12-14T07:18:26Z |
| format | Article |
| id | doaj.art-5be92261ca724c38b8bef638f98759a6 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-12-14T07:18:26Z |
| publishDate | 2018-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-5be92261ca724c38b8bef638f98759a62022-12-21T23:11:39ZengDe GruyterOpen Medicine2391-54632018-03-01131909510.1515/med-2018-0014med-2018-0014Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language RegressionZhang Lin0Li Kailong1Zhang Chengqi2Qi Xianlong3Zheng Ning4Wang Guangbin5Department of MR, Shandong Medical Imaging Research Institute, Shandong University, Jinan, 250021, ChinaDepartment of Ultrasound Diagnosis, Affiliated Hospital of Jining Medical University, Jining272029, ChinaDepartment of Medical Imaging, Qianfoshan Hospital, Affiliated to Shandong University, Jinan250014, ChinaDepartment of Radiology, Jining No.1 People’s Hospital, Jining272011, ChinaDepartment of Radiology, Jining No.1 People’s Hospital, Jining272011, ChinaDepartment of MR, Shandong Medical Imaging Research Institute, Shandong University, Jinan, 250021, ChinaLanguage regression is observed in a subset of toddlers with autism spectrum disorder (ASD) as initial symptom. However, such a phenomenon has not been fully explored, partly due to the lack of definite diagnostic evaluation methods and criteria. Materials and Methods: Fifteen toddlers with ASD exhibiting language regression and fourteen age-matched typically developing (TD) controls underwent diffusion tensor imaging (DTI). DTI parameters including fractional anisotropy (FA), average fiber length (AFL), tract volume (TV) and number of voxels (NV) were analyzed by Neuro 3D in Siemens syngo workstation. Subsequently, the data were analyzed by using IBM SPSS Statistics 22. Results: Compared with TD children, a significant reduction of FA along with an increase in TV and NV was observed in ASD children with language regression. Note that there were no significant differences between ASD and TD children in AFL of the arcuate fasciculus (AF). Conclusions: These DTI changes in the AF suggest that microstructural anomalies of the AF white matter may be associated with language deficits in ASD children exhibiting language regression starting from an early age.https://doi.org/10.1515/med-2018-0014autism spectrum disorderdiffusion tensor imaginglanguage regressionlanguage-related white matter tracttoddler |
| spellingShingle | Zhang Lin Li Kailong Zhang Chengqi Qi Xianlong Zheng Ning Wang Guangbin Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression Open Medicine autism spectrum disorder diffusion tensor imaging language regression language-related white matter tract toddler |
| title | Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression |
| title_full | Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression |
| title_fullStr | Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression |
| title_full_unstemmed | Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression |
| title_short | Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression |
| title_sort | arcuate fasciculus in autism spectrum disorder toddlers with language regression |
| topic | autism spectrum disorder diffusion tensor imaging language regression language-related white matter tract toddler |
| url | https://doi.org/10.1515/med-2018-0014 |
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