Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2
The inner ear is highly organized, with distinct domains being located across the Line of Polarity Reversal (LPR). Here they show that Emx2 establishes the LPR and bidirectional selectivity of otolith organs, and that loss of the LPR in mice affects swimming and balance.
Bibliographic Details
| Main Authors: |
Young Rae Ji,
Yosuke Tona,
Talah Wafa,
Matthew E. Christman,
Edward D. Tourney,
Tao Jiang,
Sho Ohta,
Hui Cheng,
Tracy Fitzgerald,
Bernd Fritzsch,
Sherri M. Jones,
Kathleen E. Cullen,
Doris K. Wu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-33819-3
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