Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2
The inner ear is highly organized, with distinct domains being located across the Line of Polarity Reversal (LPR). Here they show that Emx2 establishes the LPR and bidirectional selectivity of otolith organs, and that loss of the LPR in mice affects swimming and balance.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33819-3 |
| _version_ | 1811198109309468672 |
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| author | Young Rae Ji Yosuke Tona Talah Wafa Matthew E. Christman Edward D. Tourney Tao Jiang Sho Ohta Hui Cheng Tracy Fitzgerald Bernd Fritzsch Sherri M. Jones Kathleen E. Cullen Doris K. Wu |
| author_facet | Young Rae Ji Yosuke Tona Talah Wafa Matthew E. Christman Edward D. Tourney Tao Jiang Sho Ohta Hui Cheng Tracy Fitzgerald Bernd Fritzsch Sherri M. Jones Kathleen E. Cullen Doris K. Wu |
| author_sort | Young Rae Ji |
| collection | DOAJ |
| description | The inner ear is highly organized, with distinct domains being located across the Line of Polarity Reversal (LPR). Here they show that Emx2 establishes the LPR and bidirectional selectivity of otolith organs, and that loss of the LPR in mice affects swimming and balance. |
| first_indexed | 2024-04-12T01:25:21Z |
| format | Article |
| id | doaj.art-5bead77669984065ab06d028bf6cb8e4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T01:25:21Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5bead77669984065ab06d028bf6cb8e42022-12-22T03:53:40ZengNature PortfolioNature Communications2041-17232022-10-0113111410.1038/s41467-022-33819-3Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2Young Rae Ji0Yosuke Tona1Talah Wafa2Matthew E. Christman3Edward D. Tourney4Tao Jiang5Sho Ohta6Hui Cheng7Tracy Fitzgerald8Bernd Fritzsch9Sherri M. Jones10Kathleen E. Cullen11Doris K. Wu12Section on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthSection on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthMouse Auditory Testing Core Facility, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineSection on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthSection on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthBioinformatics and Biostatistics Collaboration Core, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthMouse Auditory Testing Core Facility, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthDepartment of Biology & Department of Otolaryngology, University of IowaDepartment of Special Education and Communication Disorders, 301 Barkley Memorial Center, University of Nebraska-LincolnDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineSection on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthThe inner ear is highly organized, with distinct domains being located across the Line of Polarity Reversal (LPR). Here they show that Emx2 establishes the LPR and bidirectional selectivity of otolith organs, and that loss of the LPR in mice affects swimming and balance.https://doi.org/10.1038/s41467-022-33819-3 |
| spellingShingle | Young Rae Ji Yosuke Tona Talah Wafa Matthew E. Christman Edward D. Tourney Tao Jiang Sho Ohta Hui Cheng Tracy Fitzgerald Bernd Fritzsch Sherri M. Jones Kathleen E. Cullen Doris K. Wu Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2 Nature Communications |
| title | Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2 |
| title_full | Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2 |
| title_fullStr | Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2 |
| title_full_unstemmed | Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2 |
| title_short | Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2 |
| title_sort | function of bidirectional sensitivity in the otolith organs established by transcription factor emx2 |
| url | https://doi.org/10.1038/s41467-022-33819-3 |
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