Chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti-inflammatory drugs
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most effective medications in modern pharmacotherapy. At the same time, it has been established that NSAIDs can cause cardiovascular diseases. Glucosamine sulfate (GS) is used in the therapy of osteoarthritis and, according to experimental...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2019-03-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/898 |
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| author | O. A. Gromova I. Yu. Torshin A. M. Lila A. V. Naumov K. V. Rudakov |
| author_facet | O. A. Gromova I. Yu. Torshin A. M. Lila A. V. Naumov K. V. Rudakov |
| author_sort | O. A. Gromova |
| collection | DOAJ |
| description | Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most effective medications in modern pharmacotherapy. At the same time, it has been established that NSAIDs can cause cardiovascular diseases. Glucosamine sulfate (GS) is used in the therapy of osteoarthritis and, according to experimental data; it can exert an antithrombotic effect. This paper evaluates the antithrombotic effects of GS and a number of NSAIDs (such as, acetylsalicylic acid (ASA), dexketoprofen, diclofenac, and meloxicam) through chemoreactome analysis. It has been found that the antithrombotic effects of GS can be on average only 1.5—3 times weaker than those of the NSAIDs studied. The findings may suggest that GS can enhance the antithrombotic effect of ASA, in particular in the presence of cardiovascular disease in patients with osteoarthritis. |
| first_indexed | 2024-04-10T02:06:18Z |
| format | Article |
| id | doaj.art-5beb0850004a4d9a8f9fa12bac4c88af |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:06:18Z |
| publishDate | 2019-03-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-5beb0850004a4d9a8f9fa12bac4c88af2023-03-13T08:39:26ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2019-03-0113112913410.14412/1996-7012-2019-1-129-1342159Chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti-inflammatory drugsO. A. Gromova0I. Yu. Torshin1A. M. Lila2A. V. Naumov3K. V. Rudakov4Федеральный исследовательский центр «Информатика и управление» Российской академии наукФедеральный исследовательский центр «Информатика и управление» Российской академии наукФГБНУ Научно-исследовательский институт ревматологии им. В.А. НасоновойФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России — ОСП Российский геронтологический научно-клинический центрФедеральный исследовательский центр «Информатика и управление» Российской академии наукNonsteroidal anti-inflammatory drugs (NSAIDs) are among the most effective medications in modern pharmacotherapy. At the same time, it has been established that NSAIDs can cause cardiovascular diseases. Glucosamine sulfate (GS) is used in the therapy of osteoarthritis and, according to experimental data; it can exert an antithrombotic effect. This paper evaluates the antithrombotic effects of GS and a number of NSAIDs (such as, acetylsalicylic acid (ASA), dexketoprofen, diclofenac, and meloxicam) through chemoreactome analysis. It has been found that the antithrombotic effects of GS can be on average only 1.5—3 times weaker than those of the NSAIDs studied. The findings may suggest that GS can enhance the antithrombotic effect of ASA, in particular in the presence of cardiovascular disease in patients with osteoarthritis.https://mrj.ima-press.net/mrj/article/view/898глюкозамина сульфат (сустагард артро)ацетилсалициловая кислотадекскетопрофендиклофенакмелокси-камхемореактомный анализ |
| spellingShingle | O. A. Gromova I. Yu. Torshin A. M. Lila A. V. Naumov K. V. Rudakov Chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti-inflammatory drugs Современная ревматология глюкозамина сульфат (сустагард артро) ацетилсалициловая кислота декскетопрофен диклофенак мелокси-кам хемореактомный анализ |
| title | Chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti-inflammatory drugs |
| title_full | Chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti-inflammatory drugs |
| title_fullStr | Chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti-inflammatory drugs |
| title_full_unstemmed | Chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti-inflammatory drugs |
| title_short | Chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti-inflammatory drugs |
| title_sort | chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti inflammatory drugs |
| topic | глюкозамина сульфат (сустагард артро) ацетилсалициловая кислота декскетопрофен диклофенак мелокси-кам хемореактомный анализ |
| url | https://mrj.ima-press.net/mrj/article/view/898 |
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