Age-dependent effects of body mass index across the adult life span on the risk of dementia: a cohort study with a genetic approach

Age-dependent effects of body mass index across the adult life span on the risk of dementia: a cohort study with a genetic approach

Abstract Background While a high body mass index (BMI) in midlife is associated with higher risk of dementia, high BMI in late-life may be associated with lower risk. This study combined genetic designs with longitudinal data to achieve a better understanding of this paradox. Methods We used longitu...

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Bibliographic Details
Main Authors: Ida K. Karlsson, Kelli Lehto, Margaret Gatz, Chandra A. Reynolds, Anna K. Dahl Aslan
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Medicine
Subjects:
Body mass index
Dementia
Obesity paradox
Polygenic score
Twin design
Life span
Online Access:http://link.springer.com/article/10.1186/s12916-020-01600-2

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