Stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objects
Recent research suggests that the medial temporal lobe (MTL) is involved in perception as well as in declarative memory. Amnesic patients with focal MTL lesions and semantic dementia patients showed perceptual deficits when discriminating faces and objects. Interestingly, these two patient groups sh...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-03-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00117/full |
| _version_ | 1819157472148979712 |
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| author | Victoria Chantal McLelland David eChan Susanne eFerber Susanne eFerber Morgan Dorough Barense Morgan Dorough Barense |
| author_facet | Victoria Chantal McLelland David eChan Susanne eFerber Susanne eFerber Morgan Dorough Barense Morgan Dorough Barense |
| author_sort | Victoria Chantal McLelland |
| collection | DOAJ |
| description | Recent research suggests that the medial temporal lobe (MTL) is involved in perception as well as in declarative memory. Amnesic patients with focal MTL lesions and semantic dementia patients showed perceptual deficits when discriminating faces and objects. Interestingly, these two patient groups showed different profiles of impairment for familiar and unfamiliar stimuli. For MTL amnesics, the use of familiar relative to unfamiliar stimuli improved discrimination performance. By contrast, patients with semantic dementia – a neurodegenerative condition associated with anterolateral temporal lobe damage – showed no such facilitation from familiar stimuli. Given that the two patient groups had highly overlapping patterns of damage to the perirhinal cortex, hippocampus, and temporal pole, the neuroanatomical substrates underlying their performance discrepancy were unclear. Here, we addressed this question with a multivariate reanalysis of the data presented by Barense, Henson, and Graham (2011, J. Cogn. Neurosci. 23, 3052-3067), using functional connectivity to examine how stimulus familiarity affected the broader networks with which the perirhinal cortex, hippocampus, and temporal poles interact. In this study, healthy participants were scanned while they performed an odd-one-out perceptual task involving familiar and novel faces or objects. Seed-based analyses revealed that functional connectivity of the right perirhinal cortex and right anterior hippocampus was modulated by the degree of stimulus familiarity. For familiar relative to unfamiliar faces and objects, both right perirhinal cortex and right anterior hippocampus showed enhanced functional correlations with anterior/lateral temporal cortex, temporal pole, and medial/lateral parietal cortex. These findings suggest that in order to benefit from stimulus familiarity, it is necessary to engage not only the perirhinal cortex and hippocampus, but also a network of regions known to represent semantic information. |
| first_indexed | 2024-12-22T16:09:18Z |
| format | Article |
| id | doaj.art-5beb466030bb42daa4034b06d1d0fd77 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T16:09:18Z |
| publishDate | 2014-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-5beb466030bb42daa4034b06d1d0fd772022-12-21T18:20:31ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612014-03-01810.3389/fnhum.2014.0011770809Stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objectsVictoria Chantal McLelland0David eChan1Susanne eFerber2Susanne eFerber3Morgan Dorough Barense4Morgan Dorough Barense5University of TorontoUniversity of TorontoUniversity of TorontoRotman Research InstituteUniversity of TorontoRotman Research InstituteRecent research suggests that the medial temporal lobe (MTL) is involved in perception as well as in declarative memory. Amnesic patients with focal MTL lesions and semantic dementia patients showed perceptual deficits when discriminating faces and objects. Interestingly, these two patient groups showed different profiles of impairment for familiar and unfamiliar stimuli. For MTL amnesics, the use of familiar relative to unfamiliar stimuli improved discrimination performance. By contrast, patients with semantic dementia – a neurodegenerative condition associated with anterolateral temporal lobe damage – showed no such facilitation from familiar stimuli. Given that the two patient groups had highly overlapping patterns of damage to the perirhinal cortex, hippocampus, and temporal pole, the neuroanatomical substrates underlying their performance discrepancy were unclear. Here, we addressed this question with a multivariate reanalysis of the data presented by Barense, Henson, and Graham (2011, J. Cogn. Neurosci. 23, 3052-3067), using functional connectivity to examine how stimulus familiarity affected the broader networks with which the perirhinal cortex, hippocampus, and temporal poles interact. In this study, healthy participants were scanned while they performed an odd-one-out perceptual task involving familiar and novel faces or objects. Seed-based analyses revealed that functional connectivity of the right perirhinal cortex and right anterior hippocampus was modulated by the degree of stimulus familiarity. For familiar relative to unfamiliar faces and objects, both right perirhinal cortex and right anterior hippocampus showed enhanced functional correlations with anterior/lateral temporal cortex, temporal pole, and medial/lateral parietal cortex. These findings suggest that in order to benefit from stimulus familiarity, it is necessary to engage not only the perirhinal cortex and hippocampus, but also a network of regions known to represent semantic information.http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00117/fullPerceptionfunctional connectivityFamiliarityperirhinal cortexSemantic memoryhippocampus (Hip) |
| spellingShingle | Victoria Chantal McLelland David eChan Susanne eFerber Susanne eFerber Morgan Dorough Barense Morgan Dorough Barense Stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objects Frontiers in Human Neuroscience Perception functional connectivity Familiarity perirhinal cortex Semantic memory hippocampus (Hip) |
| title | Stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objects |
| title_full | Stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objects |
| title_fullStr | Stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objects |
| title_full_unstemmed | Stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objects |
| title_short | Stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objects |
| title_sort | stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objects |
| topic | Perception functional connectivity Familiarity perirhinal cortex Semantic memory hippocampus (Hip) |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00117/full |
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