Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection
Abstract Background To compare 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) with narrow-band imaging (NBI) for cancer detection during transurethral resection of bladder tumour (TURBT). Methods Between June 2018 and October 2020, 114 patients and 282 lesions were included in t...
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-021-00946-w |
| _version_ | 1819097800098447360 |
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| author | Hiroki Hagimoto Noriyuki Makita Yuta Mine Hidetoshi Kokubun Shiori Murata Yohei Abe Masashi Kubota Naofumi Tsutsumi Toshinari Yamasaki Mutsushi Kawakita |
| author_facet | Hiroki Hagimoto Noriyuki Makita Yuta Mine Hidetoshi Kokubun Shiori Murata Yohei Abe Masashi Kubota Naofumi Tsutsumi Toshinari Yamasaki Mutsushi Kawakita |
| author_sort | Hiroki Hagimoto |
| collection | DOAJ |
| description | Abstract Background To compare 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) with narrow-band imaging (NBI) for cancer detection during transurethral resection of bladder tumour (TURBT). Methods Between June 2018 and October 2020, 114 patients and 282 lesions were included in the analysis. Patients were orally administered 5-ALA (20 mg/kg) 2 h before TURBT. The bladder was inspected with white light (WL), PDD, and NBI for each patient, and all areas positive by at least one method were resected or biopsied. The imaging data were then compared to the pathology results. Results The sensitivities of WL, PDD, and NBI for detecting urothelial carcinoma were 88.1%, 89.6%, and 76.2%, respectively. The specificity, positive predictive value, and negative predictive value for detecting urothelial carcinoma were 47.5%, 80.9%, and 61.3%, respectively, for WL; 22.5%, 74.5%, and 46.2%, respectively, for PDD; and 46.3%, 78.2%, and 43.5%, respectively, for NBI. PDD was significantly more sensitive than NBI for all lesions (p < 0.001) and carcinoma in situ (CIS) lesions (94.6% vs. 54.1%, p < 0.001). Conclusions PDD can increase the detection rate of bladder cancer, compared to NBI, by greater than 10%. Therefore, 100% of CIS lesions can be detected by adding PDD to WL. |
| first_indexed | 2024-12-22T00:20:50Z |
| format | Article |
| id | doaj.art-5bebaf1afd734df1ae4b94ba6f950e09 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-12-22T00:20:50Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-5bebaf1afd734df1ae4b94ba6f950e092022-12-21T18:45:10ZengBMCBMC Urology1471-24902021-12-012111610.1186/s12894-021-00946-wComparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detectionHiroki Hagimoto0Noriyuki Makita1Yuta Mine2Hidetoshi Kokubun3Shiori Murata4Yohei Abe5Masashi Kubota6Naofumi Tsutsumi7Toshinari Yamasaki8Mutsushi Kawakita9Department of Urology, Kobe City Medical Center General HospitalDepartment of Urology, Kobe City Medical Center General HospitalDepartment of Urology, Kobe City Medical Center General HospitalDepartment of Urology, Kobe City Medical Center General HospitalDepartment of Urology, Kobe City Medical Center General HospitalDepartment of Urology, Kobe City Medical Center General HospitalDepartment of Urology, Kobe City Medical Center General HospitalDepartment of Urology, Kobe City Medical Center General HospitalDepartment of Urology, Kobe City Medical Center General HospitalDepartment of Urology, Kobe City Medical Center General HospitalAbstract Background To compare 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) with narrow-band imaging (NBI) for cancer detection during transurethral resection of bladder tumour (TURBT). Methods Between June 2018 and October 2020, 114 patients and 282 lesions were included in the analysis. Patients were orally administered 5-ALA (20 mg/kg) 2 h before TURBT. The bladder was inspected with white light (WL), PDD, and NBI for each patient, and all areas positive by at least one method were resected or biopsied. The imaging data were then compared to the pathology results. Results The sensitivities of WL, PDD, and NBI for detecting urothelial carcinoma were 88.1%, 89.6%, and 76.2%, respectively. The specificity, positive predictive value, and negative predictive value for detecting urothelial carcinoma were 47.5%, 80.9%, and 61.3%, respectively, for WL; 22.5%, 74.5%, and 46.2%, respectively, for PDD; and 46.3%, 78.2%, and 43.5%, respectively, for NBI. PDD was significantly more sensitive than NBI for all lesions (p < 0.001) and carcinoma in situ (CIS) lesions (94.6% vs. 54.1%, p < 0.001). Conclusions PDD can increase the detection rate of bladder cancer, compared to NBI, by greater than 10%. Therefore, 100% of CIS lesions can be detected by adding PDD to WL.https://doi.org/10.1186/s12894-021-00946-wBladder cancer5-aminolevulinic acidNarrow-band imagingPhotodynamic diagnosisTransurethral resection of bladder tumour |
| spellingShingle | Hiroki Hagimoto Noriyuki Makita Yuta Mine Hidetoshi Kokubun Shiori Murata Yohei Abe Masashi Kubota Naofumi Tsutsumi Toshinari Yamasaki Mutsushi Kawakita Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection BMC Urology Bladder cancer 5-aminolevulinic acid Narrow-band imaging Photodynamic diagnosis Transurethral resection of bladder tumour |
| title | Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection |
| title_full | Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection |
| title_fullStr | Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection |
| title_full_unstemmed | Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection |
| title_short | Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection |
| title_sort | comparison between 5 aminolevulinic acid photodynamic diagnosis and narrow band imaging for bladder cancer detection |
| topic | Bladder cancer 5-aminolevulinic acid Narrow-band imaging Photodynamic diagnosis Transurethral resection of bladder tumour |
| url | https://doi.org/10.1186/s12894-021-00946-w |
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