Finite element study of a lumbar intervertebral disc nucleus replacement device
Nucleus replacement technologies are a minimally invasive alternative to spinal fusion and total disc replacement that have the potential to reduce pain and restore motion for patients with degenerative disc disease. Finite element modeling can be used to determine the biomechanics associated with...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-12-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fbioe.2016.00093/full |
| _version_ | 1828416235211063296 |
|---|---|
| author | Jessica S Coogan W. Loren Francis Travis D Eliason Todd L Bredbenner Brian D. Stemper Brian D. Stemper Narayan Yoganandan Narayan Yoganandan Frank A Pintar Frank A Pintar Daniel P. Nicolella |
| author_facet | Jessica S Coogan W. Loren Francis Travis D Eliason Todd L Bredbenner Brian D. Stemper Brian D. Stemper Narayan Yoganandan Narayan Yoganandan Frank A Pintar Frank A Pintar Daniel P. Nicolella |
| author_sort | Jessica S Coogan |
| collection | DOAJ |
| description | Nucleus replacement technologies are a minimally invasive alternative to spinal fusion and total disc replacement that have the potential to reduce pain and restore motion for patients with degenerative disc disease. Finite element modeling can be used to determine the biomechanics associated with nucleus replacement technologies. The current study focuses on a new nucleus replacement device designed as a conforming silicone implant with an internal void. A validated finite element model of the human lumbar L3-L4 motion segment was developed and used to investigate the influence of the nucleus replacement device on spine biomechanics. In addition, the effect of device design changes on biomechanics was determined. A 3D, L3-L4 finite element model was constructed from medical imaging data. Models were created with the normal intact nucleus, the nucleus replacement device, and a solid silicone implant. Probabilistic analysis was performed on the normal model to provide quantitative validation metrics. Sensitivity analysis was performed on the silicone Shore A durometer of the device. Models were loaded under axial compression followed by flexion/extension, lateral bending, or axial rotation. Compressive displacement, endplate stresses, reaction moment, and annulus stresses were determined and compared between the different models. The novel nucleus replacement device resulted in similar compressive displacement, endplate stress, and annulus stress and slightly higher reaction moment compared with the normal nucleus. The solid implant resulted in decreased displacement, increased endplate stress, decreased annulus stress, and decreased reaction moment compared with the novel device. With increasing silicone durometer, compressive displacement decreased, endplate stress increased, reaction moment increased, and annulus stress decreased. Finite element analysis was used to show that the novel nucleus replacement device results in similar biomechanics compared with the normal intact nucleus. |
| first_indexed | 2024-12-10T14:00:29Z |
| format | Article |
| id | doaj.art-5bec67cd10e54513b39ebb5a6c88c01d |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-10T14:00:29Z |
| publishDate | 2016-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-5bec67cd10e54513b39ebb5a6c88c01d2022-12-22T01:45:48ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852016-12-01410.3389/fbioe.2016.00093233020Finite element study of a lumbar intervertebral disc nucleus replacement deviceJessica S Coogan0W. Loren Francis1Travis D Eliason2Todd L Bredbenner3Brian D. Stemper4Brian D. Stemper5Narayan Yoganandan6Narayan Yoganandan7Frank A Pintar8Frank A Pintar9Daniel P. Nicolella10Southwest Research InstituteSpinal Stabilization TechnologiesSouthwest Research InstituteSouthwest Research InstituteMedical College of WisconsinClement J. Zablocki Veterans Affairs Medical CenterMedical College of WisconsinClement J. Zablocki Veterans Affairs Medical CenterMedical College of WisconsinClement J. Zablocki Veterans Affairs Medical CenterSouthwest Research InstituteNucleus replacement technologies are a minimally invasive alternative to spinal fusion and total disc replacement that have the potential to reduce pain and restore motion for patients with degenerative disc disease. Finite element modeling can be used to determine the biomechanics associated with nucleus replacement technologies. The current study focuses on a new nucleus replacement device designed as a conforming silicone implant with an internal void. A validated finite element model of the human lumbar L3-L4 motion segment was developed and used to investigate the influence of the nucleus replacement device on spine biomechanics. In addition, the effect of device design changes on biomechanics was determined. A 3D, L3-L4 finite element model was constructed from medical imaging data. Models were created with the normal intact nucleus, the nucleus replacement device, and a solid silicone implant. Probabilistic analysis was performed on the normal model to provide quantitative validation metrics. Sensitivity analysis was performed on the silicone Shore A durometer of the device. Models were loaded under axial compression followed by flexion/extension, lateral bending, or axial rotation. Compressive displacement, endplate stresses, reaction moment, and annulus stresses were determined and compared between the different models. The novel nucleus replacement device resulted in similar compressive displacement, endplate stress, and annulus stress and slightly higher reaction moment compared with the normal nucleus. The solid implant resulted in decreased displacement, increased endplate stress, decreased annulus stress, and decreased reaction moment compared with the novel device. With increasing silicone durometer, compressive displacement decreased, endplate stress increased, reaction moment increased, and annulus stress decreased. Finite element analysis was used to show that the novel nucleus replacement device results in similar biomechanics compared with the normal intact nucleus.http://journal.frontiersin.org/Journal/10.3389/fbioe.2016.00093/fullIntervertebral Discspine biomechanicsFinite Element ModelingDegenerative discNucleus replacementFinite Element Analysis |
| spellingShingle | Jessica S Coogan W. Loren Francis Travis D Eliason Todd L Bredbenner Brian D. Stemper Brian D. Stemper Narayan Yoganandan Narayan Yoganandan Frank A Pintar Frank A Pintar Daniel P. Nicolella Finite element study of a lumbar intervertebral disc nucleus replacement device Frontiers in Bioengineering and Biotechnology Intervertebral Disc spine biomechanics Finite Element Modeling Degenerative disc Nucleus replacement Finite Element Analysis |
| title | Finite element study of a lumbar intervertebral disc nucleus replacement device |
| title_full | Finite element study of a lumbar intervertebral disc nucleus replacement device |
| title_fullStr | Finite element study of a lumbar intervertebral disc nucleus replacement device |
| title_full_unstemmed | Finite element study of a lumbar intervertebral disc nucleus replacement device |
| title_short | Finite element study of a lumbar intervertebral disc nucleus replacement device |
| title_sort | finite element study of a lumbar intervertebral disc nucleus replacement device |
| topic | Intervertebral Disc spine biomechanics Finite Element Modeling Degenerative disc Nucleus replacement Finite Element Analysis |
| url | http://journal.frontiersin.org/Journal/10.3389/fbioe.2016.00093/full |
| work_keys_str_mv | AT jessicascoogan finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice AT wlorenfrancis finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice AT travisdeliason finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice AT toddlbredbenner finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice AT briandstemper finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice AT briandstemper finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice AT narayanyoganandan finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice AT narayanyoganandan finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice AT frankapintar finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice AT frankapintar finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice AT danielpnicolella finiteelementstudyofalumbarintervertebraldiscnucleusreplacementdevice |