Role of m6A modification in dysregulation of Wnt/β-catenin pathway in cancer
N6-methyladenosine (m6A) modification is the most abundant post-transcriptional regulation of RNAs in eukaryotes. Dysregulation of m6A readers, writers, and erasers can significantly promote tumorigenesis by altering the expression of various genes. Wnt/β-catenin is an evolutionarily conserved signa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222014123 |
| _version_ | 1811299667611222016 |
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| author | Peyman Tabnak Yaser Ghasemi Mohammad Natami Roya Khorram Mohammad Ebrahimnezhad |
| author_facet | Peyman Tabnak Yaser Ghasemi Mohammad Natami Roya Khorram Mohammad Ebrahimnezhad |
| author_sort | Peyman Tabnak |
| collection | DOAJ |
| description | N6-methyladenosine (m6A) modification is the most abundant post-transcriptional regulation of RNAs in eukaryotes. Dysregulation of m6A readers, writers, and erasers can significantly promote tumorigenesis by altering the expression of various genes. Wnt/β-catenin is an evolutionarily conserved signaling pathway that has recently been linked to the pathogenesis of many cancers. Given the significance of this pathway in regulating normal tissue homeostasis and stem cell differentiation, a subtle understanding of the molecular mechanism underlying its dysregulation is required for effective targeting. There is mounting evidence that m6A regulators are highly implicated in the dysregulation of the Wnt/β-catenin signaling pathway. Since m6A regulators can affect Wnt pathway components and dysregulation of either leads to carcinogenesis, this study aims to clarify the relationship between m6A regulators and the Wnt/β-catenin signaling pathway to investigate their combined impact on tumorigenesis. |
| first_indexed | 2024-04-13T06:40:08Z |
| format | Article |
| id | doaj.art-5bee492717e24c5cb925f317451a02b4 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T06:40:08Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-5bee492717e24c5cb925f317451a02b42022-12-22T02:57:46ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-01-01157114023Role of m6A modification in dysregulation of Wnt/β-catenin pathway in cancerPeyman Tabnak0Yaser Ghasemi1Mohammad Natami2Roya Khorram3Mohammad Ebrahimnezhad4Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran; Corresponding author.Faculty of Pharmacy, Ramsar Campus, Mazandaran University of Medical Sciences, Ramsar, IranDepartment of Urology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, IranBone and Joint Diseases Research Center, Department of Orthopedic Surgery, Shiraz University of Medical Sciences, Shiraz, IranFaculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5165665931, IranN6-methyladenosine (m6A) modification is the most abundant post-transcriptional regulation of RNAs in eukaryotes. Dysregulation of m6A readers, writers, and erasers can significantly promote tumorigenesis by altering the expression of various genes. Wnt/β-catenin is an evolutionarily conserved signaling pathway that has recently been linked to the pathogenesis of many cancers. Given the significance of this pathway in regulating normal tissue homeostasis and stem cell differentiation, a subtle understanding of the molecular mechanism underlying its dysregulation is required for effective targeting. There is mounting evidence that m6A regulators are highly implicated in the dysregulation of the Wnt/β-catenin signaling pathway. Since m6A regulators can affect Wnt pathway components and dysregulation of either leads to carcinogenesis, this study aims to clarify the relationship between m6A regulators and the Wnt/β-catenin signaling pathway to investigate their combined impact on tumorigenesis.http://www.sciencedirect.com/science/article/pii/S0753332222014123N6-methyladenosineEpigeneticWnt/β-cateninSignaling pathwayCancerm6A writers |
| spellingShingle | Peyman Tabnak Yaser Ghasemi Mohammad Natami Roya Khorram Mohammad Ebrahimnezhad Role of m6A modification in dysregulation of Wnt/β-catenin pathway in cancer Biomedicine & Pharmacotherapy N6-methyladenosine Epigenetic Wnt/β-catenin Signaling pathway Cancer m6A writers |
| title | Role of m6A modification in dysregulation of Wnt/β-catenin pathway in cancer |
| title_full | Role of m6A modification in dysregulation of Wnt/β-catenin pathway in cancer |
| title_fullStr | Role of m6A modification in dysregulation of Wnt/β-catenin pathway in cancer |
| title_full_unstemmed | Role of m6A modification in dysregulation of Wnt/β-catenin pathway in cancer |
| title_short | Role of m6A modification in dysregulation of Wnt/β-catenin pathway in cancer |
| title_sort | role of m6a modification in dysregulation of wnt β catenin pathway in cancer |
| topic | N6-methyladenosine Epigenetic Wnt/β-catenin Signaling pathway Cancer m6A writers |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222014123 |
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