Memantine Attenuates Cocaine and neuroHIV Neurotoxicity in the Medial Prefrontal Cortex

Memantine Attenuates Cocaine and neuroHIV Neurotoxicity in the Medial Prefrontal Cortex

Individuals with substance use disorder are at a higher risk of contracting HIV and progress more rapidly to AIDS as drugs of abuse, such as cocaine, potentiate the neurotoxic effects of HIV-associated proteins including, but not limited to, HIV-1 trans-activator of transcription (Tat) and the envel...

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Bibliographic Details
Main Authors: Congwu Du, Yueming Hua, Kevin Clare, Kicheon Park, Craig P. Allen, Nora D. Volkow, Xiu-Ti Hu, Yingtian Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
NMDA antagonist
addiction
neuroHIV
imaging
prefrontal cortex
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.895006/full

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