Ajuforrestin A, an Abietane Diterpenoid from <i>Ajuga ovalifolia</i> var. <i>calanthe</i>, Induces A549 Cell Apoptosis by Targeting SHP2

Ajuforrestin A, an Abietane Diterpenoid from <i>Ajuga ovalifolia</i> var. <i>calanthe</i>, Induces A549 Cell Apoptosis by Targeting SHP2

The Src-homology 2 domain-containing phosphatase 2 (SHP2), which is encoded by PTPN11, participates in many cellular signaling pathways and is closely related to various tumorigenesis. Inhibition of the abnormal activity of SHP2 by small molecules is an important part of cancer treatment. Here, thre...

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Bibliographic Details
Main Authors: Hongling Yan, Miao Jiang, Fujin Yang, Xueyong Tang, Mao Lin, Chunyan Zhou, Yuzhu Tan, Deming Liu
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
SHP2
Ajuforrestin A
<i>Ajuga ovalifolia</i> var. <i>calantha</i>
apoptosis
ERK/AKT pathway
Online Access:https://www.mdpi.com/1420-3049/27/17/5469

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