The Potential Role of Bioactive Plasmalogens in Lung Surfactant
Neonatal respiratory distress syndrome (NRDS) is a type of newborn disorder caused by the deficiency or late appearance of lung surfactant, a mixture of lipids and proteins. Studies have shown that lung surfactant replacement therapy could effectively reduce the morbidity and mortality of NRDS, and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.618102/full |
| _version_ | 1818949863733198848 |
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| author | Ruijiang Zhuo Pu Rong Jieli Wang Rokshana Parvin Yuru Deng Yuru Deng |
| author_facet | Ruijiang Zhuo Pu Rong Jieli Wang Rokshana Parvin Yuru Deng Yuru Deng |
| author_sort | Ruijiang Zhuo |
| collection | DOAJ |
| description | Neonatal respiratory distress syndrome (NRDS) is a type of newborn disorder caused by the deficiency or late appearance of lung surfactant, a mixture of lipids and proteins. Studies have shown that lung surfactant replacement therapy could effectively reduce the morbidity and mortality of NRDS, and the therapeutic effect of animal-derived surfactant preparation, although with its limitations, performs much better than that of protein-free synthetic ones. Plasmalogens are a type of ether phospholipids present in multiple human tissues, including lung and lung surfactant. Plasmalogens are known to promote and stabilize non-lamellar hexagonal phase structure in addition to their significant antioxidant property. Nevertheless, they are nearly ignored and underappreciated in the lung surfactant-related research. This report will focus on plasmalogens, a minor yet potentially vital component of lung surfactant, and also discuss their biophysical properties and functions as anti-oxidation, structural modification, and surface tension reduction at the alveolar surface. At the end, we boldly propose a novel synthetic protein-free lung surfactant preparation with plasmalogen modification as an alternative strategy for surfactant replacement therapy. |
| first_indexed | 2024-12-20T09:09:27Z |
| format | Article |
| id | doaj.art-5bf0fe66e2bf4c2a94da1cf653225537 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-20T09:09:27Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-5bf0fe66e2bf4c2a94da1cf6532255372022-12-21T19:45:37ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-02-01910.3389/fcell.2021.618102618102The Potential Role of Bioactive Plasmalogens in Lung SurfactantRuijiang Zhuo0Pu Rong1Jieli Wang2Rokshana Parvin3Yuru Deng4Yuru Deng5Eye Hospital, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaEye Hospital, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaNeonatal respiratory distress syndrome (NRDS) is a type of newborn disorder caused by the deficiency or late appearance of lung surfactant, a mixture of lipids and proteins. Studies have shown that lung surfactant replacement therapy could effectively reduce the morbidity and mortality of NRDS, and the therapeutic effect of animal-derived surfactant preparation, although with its limitations, performs much better than that of protein-free synthetic ones. Plasmalogens are a type of ether phospholipids present in multiple human tissues, including lung and lung surfactant. Plasmalogens are known to promote and stabilize non-lamellar hexagonal phase structure in addition to their significant antioxidant property. Nevertheless, they are nearly ignored and underappreciated in the lung surfactant-related research. This report will focus on plasmalogens, a minor yet potentially vital component of lung surfactant, and also discuss their biophysical properties and functions as anti-oxidation, structural modification, and surface tension reduction at the alveolar surface. At the end, we boldly propose a novel synthetic protein-free lung surfactant preparation with plasmalogen modification as an alternative strategy for surfactant replacement therapy.https://www.frontiersin.org/articles/10.3389/fcell.2021.618102/fulllung surfactantplasmalogentubular myelinlamellar bodiesantioxidantcubic membrane |
| spellingShingle | Ruijiang Zhuo Pu Rong Jieli Wang Rokshana Parvin Yuru Deng Yuru Deng The Potential Role of Bioactive Plasmalogens in Lung Surfactant Frontiers in Cell and Developmental Biology lung surfactant plasmalogen tubular myelin lamellar bodies antioxidant cubic membrane |
| title | The Potential Role of Bioactive Plasmalogens in Lung Surfactant |
| title_full | The Potential Role of Bioactive Plasmalogens in Lung Surfactant |
| title_fullStr | The Potential Role of Bioactive Plasmalogens in Lung Surfactant |
| title_full_unstemmed | The Potential Role of Bioactive Plasmalogens in Lung Surfactant |
| title_short | The Potential Role of Bioactive Plasmalogens in Lung Surfactant |
| title_sort | potential role of bioactive plasmalogens in lung surfactant |
| topic | lung surfactant plasmalogen tubular myelin lamellar bodies antioxidant cubic membrane |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.618102/full |
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