Phototherapeutic keratectomy for epithelial basement membrane dystrophy
Wen-Shin Lee, Carson K Lam, Edward E Manche Department of Ophthalmology, Stanford University, Stanford, CA, USA Purpose: The purpose of this study was to evaluate the long-term efficacy of phototherapeutic keratectomy (PTK) in treating epithelial basement membrane dystrophy (EBMD).Methods: Preoper...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2016-12-01
|
| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/phototherapeutic-keratectomy-for-epithelial-basement-membrane-dystroph-peer-reviewed-article-OPTH |
| _version_ | 1819129993228189696 |
|---|---|
| author | Lee WS Lam CK Manche EE |
| author_facet | Lee WS Lam CK Manche EE |
| author_sort | Lee WS |
| collection | DOAJ |
| description | Wen-Shin Lee, Carson K Lam, Edward E Manche Department of Ophthalmology, Stanford University, Stanford, CA, USA Purpose: The purpose of this study was to evaluate the long-term efficacy of phototherapeutic keratectomy (PTK) in treating epithelial basement membrane dystrophy (EBMD).Methods: Preoperative and postoperative records were reviewed for 58 eyes of 51 patients with >3 months follow-up (range 3−170 months) treated for EBMD with PTK after failure of conservative medical treatment at Byers Eye Institute of Stanford University. Symptoms, clinical findings, and corrected distance visual acuity (CDVA) were assessed. The primary outcome measure was symptomatic recurrence as measured by erosions or visual complaints >3 months after successful PTK.Results: For eyes with visual disturbances (n=30), preoperative CDVA was ~20/32 (0.24 LogMAR, SD 0.21) and postoperative CDVA was ~20/25 (0.07 LogMAR, SD 0.12; P<0.0001). Twenty-six eyes (86.7%) responded to treatment, with symptomatic recurrence in 6 eyes (23.1%) at an average of 37.7 months (SD 42.8). For eyes with painful erosions (n=29), preoperative CDVA was ~20/25 (0.12, SD 0.19) and postoperative CDVA was ~20/20 (0.05. SD 0.16; P=0.0785). Twenty-three eyes (79.3%) responded to treatment, with symptomatic recurrence in 3 eyes (13.0%) at an average of 9.7 months (SD 1.5). The probability of being recurrence free after a successful treatment for visual disturbances and erosions at 5 years postoperatively was estimated at 83.0% (95% confidence interval 68.7%–97.0%) and 88.0% (95% confidence interval 65.3%–96.6%), respectively.Conclusion: The majority of visual disturbances and painful erosions associated with EBMD respond to PTK. For those with a treatment response, symptomatic relief is maintained over long-term follow-up. Keywords: epithelial basement membrane dystrophy, EBMD, phototherapeutic keratectomy, PTK |
| first_indexed | 2024-12-22T08:52:32Z |
| format | Article |
| id | doaj.art-5bf16332a1cf4fb3a9c385b4319abd71 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-22T08:52:32Z |
| publishDate | 2016-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-5bf16332a1cf4fb3a9c385b4319abd712022-12-21T18:31:56ZengDove Medical PressClinical Ophthalmology1177-54832016-12-01Volume 11152230536Phototherapeutic keratectomy for epithelial basement membrane dystrophyLee WSLam CKManche EEWen-Shin Lee, Carson K Lam, Edward E Manche Department of Ophthalmology, Stanford University, Stanford, CA, USA Purpose: The purpose of this study was to evaluate the long-term efficacy of phototherapeutic keratectomy (PTK) in treating epithelial basement membrane dystrophy (EBMD).Methods: Preoperative and postoperative records were reviewed for 58 eyes of 51 patients with >3 months follow-up (range 3−170 months) treated for EBMD with PTK after failure of conservative medical treatment at Byers Eye Institute of Stanford University. Symptoms, clinical findings, and corrected distance visual acuity (CDVA) were assessed. The primary outcome measure was symptomatic recurrence as measured by erosions or visual complaints >3 months after successful PTK.Results: For eyes with visual disturbances (n=30), preoperative CDVA was ~20/32 (0.24 LogMAR, SD 0.21) and postoperative CDVA was ~20/25 (0.07 LogMAR, SD 0.12; P<0.0001). Twenty-six eyes (86.7%) responded to treatment, with symptomatic recurrence in 6 eyes (23.1%) at an average of 37.7 months (SD 42.8). For eyes with painful erosions (n=29), preoperative CDVA was ~20/25 (0.12, SD 0.19) and postoperative CDVA was ~20/20 (0.05. SD 0.16; P=0.0785). Twenty-three eyes (79.3%) responded to treatment, with symptomatic recurrence in 3 eyes (13.0%) at an average of 9.7 months (SD 1.5). The probability of being recurrence free after a successful treatment for visual disturbances and erosions at 5 years postoperatively was estimated at 83.0% (95% confidence interval 68.7%–97.0%) and 88.0% (95% confidence interval 65.3%–96.6%), respectively.Conclusion: The majority of visual disturbances and painful erosions associated with EBMD respond to PTK. For those with a treatment response, symptomatic relief is maintained over long-term follow-up. Keywords: epithelial basement membrane dystrophy, EBMD, phototherapeutic keratectomy, PTKhttps://www.dovepress.com/phototherapeutic-keratectomy-for-epithelial-basement-membrane-dystroph-peer-reviewed-article-OPTHEpithelial Basement Membrane DystrophyEBMDPhototherapeutic KeratectomyPTK |
| spellingShingle | Lee WS Lam CK Manche EE Phototherapeutic keratectomy for epithelial basement membrane dystrophy Clinical Ophthalmology Epithelial Basement Membrane Dystrophy EBMD Phototherapeutic Keratectomy PTK |
| title | Phototherapeutic keratectomy for epithelial basement membrane dystrophy |
| title_full | Phototherapeutic keratectomy for epithelial basement membrane dystrophy |
| title_fullStr | Phototherapeutic keratectomy for epithelial basement membrane dystrophy |
| title_full_unstemmed | Phototherapeutic keratectomy for epithelial basement membrane dystrophy |
| title_short | Phototherapeutic keratectomy for epithelial basement membrane dystrophy |
| title_sort | phototherapeutic keratectomy for epithelial basement membrane dystrophy |
| topic | Epithelial Basement Membrane Dystrophy EBMD Phototherapeutic Keratectomy PTK |
| url | https://www.dovepress.com/phototherapeutic-keratectomy-for-epithelial-basement-membrane-dystroph-peer-reviewed-article-OPTH |
| work_keys_str_mv | AT leews phototherapeutickeratectomyforepithelialbasementmembranedystrophy AT lamck phototherapeutickeratectomyforepithelialbasementmembranedystrophy AT mancheee phototherapeutickeratectomyforepithelialbasementmembranedystrophy |