THE STRUCTURE OF THE LIPID PHASE OF THE ERYTHROCYTE MEMBRANE IN PATIENTS WITH EXPRESSED HEMOLYSIS AFTER SURGERY WITH CARDIOPULMONARY BYPASS
The composition of lipid phase of red-cell membrane in patients with ischemic heart disease (IHD) with pronounced postperfusion hemolysis (18 patients) before coronary artery bypass surgery and 1 hour after the completion of cardia bypass (CB) has been studied. It is shown that patients with IHD wit...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2013-02-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/42 |
| _version_ | 1797872966760923136 |
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| author | O. A. Khokhlov |
| author_facet | O. A. Khokhlov |
| author_sort | O. A. Khokhlov |
| collection | DOAJ |
| description | The composition of lipid phase of red-cell membrane in patients with ischemic heart disease (IHD) with pronounced postperfusion hemolysis (18 patients) before coronary artery bypass surgery and 1 hour after the completion of cardia bypass (CB) has been studied. It is shown that patients with IHD with pronounced hemolysis are characterized by the normal ratio of phospholipids (PL) fractions in red-cell membrane before surgery, which is connected with eth high content of young forms of red cells in blood at this stage. After surgery, the fraction of lysophosphatidylcholine and phosphatidic acid in red-cell membrane increases against the background of decrease of phosphatidylinositol and phosphatidylcholine, which likely reflects the simultaneous activation of phospholipases of three classes (A, C, and D) in red cells during CB. Regardless of the phase of the study, the total content of PL in red-cell membrane of IHD patients with pronounced hemolysis is decrease at the high level of cholesterol (CS) and the CS/Pl ratio. |
| first_indexed | 2024-04-10T01:08:37Z |
| format | Article |
| id | doaj.art-5bf36750db984b7f83c2999c5d53aaee |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:08:37Z |
| publishDate | 2013-02-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-5bf36750db984b7f83c2999c5d53aaee2023-03-13T09:58:18ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842013-02-01121757910.20538/1682-0363-2013-1-75-7942THE STRUCTURE OF THE LIPID PHASE OF THE ERYTHROCYTE MEMBRANE IN PATIENTS WITH EXPRESSED HEMOLYSIS AFTER SURGERY WITH CARDIOPULMONARY BYPASSO. A. Khokhlov0Сибирский государственный медицинский университет, ТомскThe composition of lipid phase of red-cell membrane in patients with ischemic heart disease (IHD) with pronounced postperfusion hemolysis (18 patients) before coronary artery bypass surgery and 1 hour after the completion of cardia bypass (CB) has been studied. It is shown that patients with IHD with pronounced hemolysis are characterized by the normal ratio of phospholipids (PL) fractions in red-cell membrane before surgery, which is connected with eth high content of young forms of red cells in blood at this stage. After surgery, the fraction of lysophosphatidylcholine and phosphatidic acid in red-cell membrane increases against the background of decrease of phosphatidylinositol and phosphatidylcholine, which likely reflects the simultaneous activation of phospholipases of three classes (A, C, and D) in red cells during CB. Regardless of the phase of the study, the total content of PL in red-cell membrane of IHD patients with pronounced hemolysis is decrease at the high level of cholesterol (CS) and the CS/Pl ratio.https://bulletin.ssmu.ru/jour/article/view/42эритроцитыфосфолипидыискусственное кровообращение |
| spellingShingle | O. A. Khokhlov THE STRUCTURE OF THE LIPID PHASE OF THE ERYTHROCYTE MEMBRANE IN PATIENTS WITH EXPRESSED HEMOLYSIS AFTER SURGERY WITH CARDIOPULMONARY BYPASS Бюллетень сибирской медицины эритроциты фосфолипиды искусственное кровообращение |
| title | THE STRUCTURE OF THE LIPID PHASE OF THE ERYTHROCYTE MEMBRANE IN PATIENTS WITH EXPRESSED HEMOLYSIS AFTER SURGERY WITH CARDIOPULMONARY BYPASS |
| title_full | THE STRUCTURE OF THE LIPID PHASE OF THE ERYTHROCYTE MEMBRANE IN PATIENTS WITH EXPRESSED HEMOLYSIS AFTER SURGERY WITH CARDIOPULMONARY BYPASS |
| title_fullStr | THE STRUCTURE OF THE LIPID PHASE OF THE ERYTHROCYTE MEMBRANE IN PATIENTS WITH EXPRESSED HEMOLYSIS AFTER SURGERY WITH CARDIOPULMONARY BYPASS |
| title_full_unstemmed | THE STRUCTURE OF THE LIPID PHASE OF THE ERYTHROCYTE MEMBRANE IN PATIENTS WITH EXPRESSED HEMOLYSIS AFTER SURGERY WITH CARDIOPULMONARY BYPASS |
| title_short | THE STRUCTURE OF THE LIPID PHASE OF THE ERYTHROCYTE MEMBRANE IN PATIENTS WITH EXPRESSED HEMOLYSIS AFTER SURGERY WITH CARDIOPULMONARY BYPASS |
| title_sort | structure of the lipid phase of the erythrocyte membrane in patients with expressed hemolysis after surgery with cardiopulmonary bypass |
| topic | эритроциты фосфолипиды искусственное кровообращение |
| url | https://bulletin.ssmu.ru/jour/article/view/42 |
| work_keys_str_mv | AT oakhokhlov thestructureofthelipidphaseoftheerythrocytemembraneinpatientswithexpressedhemolysisaftersurgerywithcardiopulmonarybypass AT oakhokhlov structureofthelipidphaseoftheerythrocytemembraneinpatientswithexpressedhemolysisaftersurgerywithcardiopulmonarybypass |