Dietary phytate induces subclinical mechanical allodynia in mice
Neuropathic pain is a condition with varying origins, including reduced dietary micronutrient intake. Phytate is a polyphosphate found in seeds and grains that can act as an antinutrient due to the ability of sequester essential divalent metals. Here we tested whether moderate dietary phytate intake...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2023-11-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100684&tlng=en |
| _version_ | 1797635108874747904 |
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| author | D.O. Matias T. Sisnande A.F. Martins M.J. do Amaral B.L.R. Santos A.L.P. Miranda L.M.T.R. Lima |
| author_facet | D.O. Matias T. Sisnande A.F. Martins M.J. do Amaral B.L.R. Santos A.L.P. Miranda L.M.T.R. Lima |
| author_sort | D.O. Matias |
| collection | DOAJ |
| description | Neuropathic pain is a condition with varying origins, including reduced dietary micronutrient intake. Phytate is a polyphosphate found in seeds and grains that can act as an antinutrient due to the ability of sequester essential divalent metals. Here we tested whether moderate dietary phytate intake could alter nociceptive pain. We subjected weaning mice to a chow supplemented with 1% phytate for eight weeks. Body weight gain, glycemic responses, food ingestion, water ingestion, and liver and adipose tissue weights were not altered compared to controls. We observed a decreased mechanical allodynia threshold in the intervention group, although there were no changes in heat- or cold-induced pain. Animals consuming phytate showed reduced spinal cord tumor necrosis factor (TNF), indicating altered inflammatory process. These data provide evidence for a subclinical induction of mechanical allodynia that is independent of phytate consumption in animals with otherwise normal phenotypic pattern. |
| first_indexed | 2024-03-11T12:16:40Z |
| format | Article |
| id | doaj.art-5bf3b1893d954967a599b5a339980608 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-03-11T12:16:40Z |
| publishDate | 2023-11-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-5bf3b1893d954967a599b5a3399806082023-11-07T07:43:17ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2023-11-015610.1590/1414-431x2023e12955Dietary phytate induces subclinical mechanical allodynia in miceD.O. Matiashttps://orcid.org/0000-0002-0091-7201T. Sisnandehttps://orcid.org/0000-0002-9474-0581A.F. Martinshttps://orcid.org/0000-0002-5281-6250M.J. do Amaralhttps://orcid.org/0000-0003-1247-2606B.L.R. Santoshttps://orcid.org/0000-0002-6731-6451A.L.P. Mirandahttps://orcid.org/0000-0002-4410-9521L.M.T.R. Limahttps://orcid.org/0000-0001-6020-0504Neuropathic pain is a condition with varying origins, including reduced dietary micronutrient intake. Phytate is a polyphosphate found in seeds and grains that can act as an antinutrient due to the ability of sequester essential divalent metals. Here we tested whether moderate dietary phytate intake could alter nociceptive pain. We subjected weaning mice to a chow supplemented with 1% phytate for eight weeks. Body weight gain, glycemic responses, food ingestion, water ingestion, and liver and adipose tissue weights were not altered compared to controls. We observed a decreased mechanical allodynia threshold in the intervention group, although there were no changes in heat- or cold-induced pain. Animals consuming phytate showed reduced spinal cord tumor necrosis factor (TNF), indicating altered inflammatory process. These data provide evidence for a subclinical induction of mechanical allodynia that is independent of phytate consumption in animals with otherwise normal phenotypic pattern.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100684&tlng=enPhytateAllodyniaPainMicronutrientInflammation |
| spellingShingle | D.O. Matias T. Sisnande A.F. Martins M.J. do Amaral B.L.R. Santos A.L.P. Miranda L.M.T.R. Lima Dietary phytate induces subclinical mechanical allodynia in mice Brazilian Journal of Medical and Biological Research Phytate Allodynia Pain Micronutrient Inflammation |
| title | Dietary phytate induces subclinical mechanical allodynia in mice |
| title_full | Dietary phytate induces subclinical mechanical allodynia in mice |
| title_fullStr | Dietary phytate induces subclinical mechanical allodynia in mice |
| title_full_unstemmed | Dietary phytate induces subclinical mechanical allodynia in mice |
| title_short | Dietary phytate induces subclinical mechanical allodynia in mice |
| title_sort | dietary phytate induces subclinical mechanical allodynia in mice |
| topic | Phytate Allodynia Pain Micronutrient Inflammation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100684&tlng=en |
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