Presence of novel triple mutations in the pvdhfr from Plasmodium vivax in Mangaluru city area in the southwestern coastal region of India

Presence of novel triple mutations in the pvdhfr from Plasmodium vivax in Mangaluru city area in the southwestern coastal region of India

Abstract Background Genes encoding dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) are the targets of sulfadoxine–pyrimethamine (SP) present in artemisinin based combination therapy (ACT; artesunate + sulfadoxine pyrimethamine) for Plasmodium falciparum. Although SP is generally n...

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Bibliographic Details
Main Authors: Shiny Joy, Susanta K. Ghosh, Rajeshwara N. Achur, D. Channe Gowda, Namita Surolia
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Malaria Journal
Subjects:
Dihydrofolate reductase
Dihydropteroate synthase
Single nucleotide polymorphisms
Restriction fragment length polymorphisms
Sulfadoxine/pyrimethamine
Mangaluru
Online Access:http://link.springer.com/article/10.1186/s12936-018-2316-3

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